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Makale Tam Makale Uluslararası 2010

Haloperidol-Induced Neuronal Damage in Guinea Pig Hippocampus: A Microscopic Study

Elvan ÖZBEK, BERRİN ZÜHAL ALTUNKAYNAK, Mehmet Dumlu Aydın, Nazan Aydin, Özgen Vuraler, Bunyamin Unal

JOURNAL OF NEUROLOGICAL SCIENCES-TURKISH Cilt 27 · Sayı 4 · ss. 438–445 · 01.01.2010

Özet

Haloperidol, a neuroleptic drug, is still discussed if it is neurotoxic. In the present study, neurotoxic effects of haloperidol on guinea pig hippocampus were examined. Sixteen guinea pigs were randomly divided into two groups of 8 animals each. The animals of treatment group were given intraperitoneally (i.p.) haloperidol diluted in saline (dose of 5 mg/kg daily) for 6 weeks. Control animals received only the same volume of saline i.p. Hippocampi from both groups were examined by light and electron microscope. Numerous dark neurons with a heterochromatic nucleus and dense cytoplasm were observed in the hippocampi of the treatment group by light microscope and ultrastructural levels. Also some neurons have increased vacuolar contents and lysosomes. These findings suggest that haloperidol leads to prominent damage of hippocampal neurons.

Anahtar kelimeler

haloperidol HIPPOCAMPUS Electron microscopy GUINEA-PIG schizophrenia ANTIPSYCHOTIC-DRUGS VITAMIN-E INCREASES risperidone light microscopy substantia nigra GRANULE CELL-PROLIFERATION RAT HIPPOCAMPUS DOPAMINE-RECEPTORS NEUROGENESIS

Atıf için künye

ÖZBEK, E., ALTUNKAYNAK, B. Z., Aydın, M. D., Aydin, N., Vuraler, Ö., & Unal, B. (2010). Haloperidol-Induced Neuronal Damage in Guinea Pig Hippocampus: A Microscopic Study. JOURNAL OF NEUROLOGICAL SCIENCES-TURKISH, 27(4), 438–445.

BibTeX 
@article{ozbek2010-218452,
  author = {ÖZBEK, Elvan and ALTUNKAYNAK, BERRİN ZÜHAL and Aydın, Mehmet Dumlu and Aydin, Nazan and Vuraler, Özgen and Unal, Bunyamin},
  title = {Haloperidol-Induced Neuronal Damage in Guinea Pig Hippocampus: A Microscopic Study},
  journal = {JOURNAL OF NEUROLOGICAL SCIENCES-TURKISH},
  year = {2010},
  volume = {27},
  number = {4},
  pages = {438--445},
  issn = {1302-1664},
  url = {https://akademik.atauni.edu.tr/yayinlar/218452-haloperidol-induced-neuronal-damage-in-guinea-pig-hippocampus-a-microscopic}
}