A preliminary histopathological study of the effect of agmatine on diffuse brain injury in rats
Özet
The present study evaluates the effects of agmatine oil histopathological damage following traumatic injury using a clinically relevant model of diffuse brain injury. A total of 27 male Sprague-Dawley rats weighing 200-225 g were anaesthetised and subjected to head trauma using Marmarou's impact-acceleration model. The rats were then separated into two main groups: one was treated with agmatine and the other with saline for LIP to 4 days immediately after head trauma. Rats from both groups were killed 1, 3 or 8 days post-injury. The brains were examined histopathologically and scored according to the axonal, neuronal and Vascular changes associated with diffuse brain injury. There were no significant differences between the groups at I clay or 3 days after trauma, but evaluation after 8 days revealed,I significant improvement in the group treated with agmatine. Our data indicate that agmatine has a beneficial effect in diffuse brain injury and Should be trialled for therapeutic use in the management of this condition. (c) 2008 Elsevier Ltd. All rights reserved.
Atıf için künye
Şengül, G., TAKCI, E., MALCOK, U. A., AKAR, A., ERDOGAN, F., Kadıoğlu, H. H., & AYDIN, I. H. (2008). A preliminary histopathological study of the effect of agmatine on diffuse brain injury in rats. JOURNAL OF CLINICAL NEUROSCIENCE, 15(10), 1125–1129. https://doi.org/10.1016/j.jocn.2007.11.005
BibTeX
@article{sengul2008-218168,
author = {Şengül, Gökşin and TAKCI, Ethan and MALCOK, Umit Ali and AKAR, All and ERDOGAN, Fazli and Kadıoğlu, Hakan Hadi and AYDIN, Ismail Hakki},
title = {A preliminary histopathological study of the effect of agmatine on diffuse brain injury in rats},
journal = {JOURNAL OF CLINICAL NEUROSCIENCE},
year = {2008},
volume = {15},
number = {10},
pages = {1125--1129},
issn = {0967-5868},
doi = {10.1016/j.jocn.2007.11.005},
url = {https://akademik.atauni.edu.tr/yayinlar/218168-a-preliminary-histopathological-study-of-the-effect-of-agmatine-on-diffuse-brain}
}