Antioxidant effects of Nigella sativa in the treatment of experimentally induced rhinosinusitis
Özet
Aim. The objective of this study was to investigate the effect of Nigella sativa (NS) in experimental
bacterial rhinosinusitis.
Material and Methods. Bacterial rhinosinusitis was induced with Staphylococcus aureus. Rabbits
were divided into control, NS 50, NS 100 and NS 200 mg/kg/d groups. NS was given orally for 7 days.
The same volume of normal saline was given as a vehicle to the control group for the same period.
At 7 days post-treatment, mucosal samples were excised from the treated and control groups for
measurements of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), myeloperoxidase
(MPO) and malondialdehyde (MDA).
Results. SOD and GSH-Px activities significantly increased in the NS 50, NS 100 and NS 200 mg/kg/
d groups when compared with the saline treated group. MPO activity and MDA levels significantly
decreased in the NS 50, NS 100 and NS 200 mg/kg/d when compared with the saline treated group.
Conclusion. These findings show that administration of NS increased the SOD, GSH-Px activities
and decreased the lipid peroxidation and MPO activity in experimental rhinosinusitis in rabbits. NS
prevented oxidative stress by scavenging reactive oxygen species generated in rhinosinusitis model
in rabbits.
Atıf için künye
Yörük, Ö., Gür, F., Uyanik, H., Yaşar, M., Mutlu, V., Altas, E., Baysal, E., & Taysi, S. (2010). Antioxidant effects of Nigella sativa in the treatment of experimentally induced rhinosinusitis. Macedonian Journal of Medical Sciences, 3(2), 132–137. https://doi.org/10.3889/mjms.1857-5773.2010.0101
BibTeX
@article{yoruk2010-217803,
author = {Yörük, Özgür and Gür, Fatma and Uyanik, Hamidullah and Yaşar, Murat and Mutlu, Vahit and Altas, Enver and Baysal, Elif and Taysi, Seyithan},
title = {Antioxidant effects of Nigella sativa in the treatment of experimentally induced rhinosinusitis},
journal = {Macedonian Journal of Medical Sciences},
year = {2010},
volume = {3},
number = {2},
pages = {132--137},
issn = {1857-5749},
doi = {10.3889/mjms.1857-5773.2010.0101},
url = {https://akademik.atauni.edu.tr/yayinlar/217803-antioxidant-effects-of-nigella-sativa-in-the-treatment-of-experimentally-induced}
}