Effect of macrolide antibiotics on nitric oxide synthase and xanthine oxidase activities, and malondialdehyde level in erythrocyte of the guinea pigs with experimental otitis media with effusion
Özet
Although the long-term administrations of macrolide antibiotics are effective for diffuse panbronchiolitis, otitis media with effusion (OME), and some other diseases, their mechanism of action has not been fully understood. In order to elucidate the mechanisms of possible effects of macrolide antibiotics on activities of erythrocyte nitric oxide synthase (NOS), xanthine oxidase (XO), and malondialdehyde (MDA) levels in experimental OME, we aimed to evaluate the effect of macrolide antibiotics (erythromycin, azithromycin, roxithromycin, and clarithromycin) using an experimental guinea pig otitis media model.
Atıf için künye
Aktan, B., TAYSI, S., GÜMÜŞTEKİN, K., ÜÇÜNCÜ, H., MEMİŞOĞULLARI, R., SAVE, K., & BAKAN, N. (2003). Effect of macrolide antibiotics on nitric oxide synthase and xanthine oxidase activities, and malondialdehyde level in erythrocyte of the guinea pigs with experimental otitis media with effusion. POLISH JOURNAL OF PHARMACOLOGY, 55(6), 1105–1110.
BibTeX
@article{aktan2003-217467,
author = {Aktan, Bülent and TAYSI, SEYİTHAN and GÜMÜŞTEKİN, KENAN and ÜÇÜNCÜ, HARUN and MEMİŞOĞULLARI, RAMAZAN and SAVE, K and BAKAN, Nuri},
title = {Effect of macrolide antibiotics on nitric oxide synthase and xanthine oxidase activities, and malondialdehyde level in erythrocyte of the guinea pigs with experimental otitis media with effusion},
journal = {POLISH JOURNAL OF PHARMACOLOGY},
year = {2003},
volume = {55},
number = {6},
pages = {1105--1110},
issn = {1230-6002},
url = {https://akademik.atauni.edu.tr/yayinlar/217467-effect-of-macrolide-antibiotics-on-nitric-oxide-synthase-and-xanthine-oxidase}
}