A Randomized Trial Comparing Triple versus Single Uterine Tourniquet in Open Myomectomy

Background: Single and triple uterine tourniquet significantly reduces blood loss during myomectomy and both are highly effective. Triple tourniquet, however, blocks ovarian circulation and there is doubt that it causes ischemic damage to ovaries. These 2 methods have not been compared by a randomised controlled study yet. The purpose of this study was to compare triple uterine tourniquet with single tourniquet in terms of blood loss during open myomectomy. Material and Methods: Women were randomized to triple (n = 24) or to single tourniquet (n = 24) at open myomectomy. All women with a myomatous uterus greater than 12 weeks of gestation were eligible to be part of the study. The primary outcome of the study was the amount of blood loss during surgery. Sample size was set to detect a 250 mL difference in blood loss with 80% power at a = 0.05. We also compared the change in anti-Mullerian Hormone (AMH) levels before and after surgery. Results: There was no significant difference in the outcome of blood loss between triple and single uterine tourniquet (322 +/- 223 vs. 426 +/- 355 mL, p = 0.230). Change in AMH was not different between the groups. Conclusions: There is no clinically significant difference between triple and single uterine tourniquets on blood loss at open myomectomy. (C) 2017 S. Karger AG, Basel