Overexpression of c-Met in cervical intraepithelial neoplasia
Özet
Purpose of investigation: The purpose of this study is to evaluate the significance of the c-Met / Hepatocyte Growth Factor Receptor (HGFR) expression in cervical intraepithelial neoplasia (CIN). Materials and Methods: Twenty-one patients from two types of cervical intraepithelial neoplasias (LSIL and HSIL), diagnosed in our clinic were studied with c-Met immunohistochemistry. Of the 21 cases, five were diagnosed as LSIL and 16 as Normal cervical mucosas from five patients were studied with c-Met as control cases. Results: Overexpression of c-Met was found in all five of LSIL specimens. C-Met overexpression was observed in 11 cases of HSIL. No c-Met overexpression was seen in any of the five control cases. Conclusion: These results revealed that c-Met oncogene overexpression is an important parameter in cervical early oncogenesis and may have a role in malignant transformation of cervical epithelial cells.
Atıf için künye
Comunoglu, C., Boynukahn, K., Ugur, M. G., Al, R. A., Kuzey, G. M., & Baykal, C. (2012). Overexpression of c-Met in cervical intraepithelial neoplasia. EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY, 33(6), 625–628.
BibTeX
@article{comunoglu2012-216457,
author = {Comunoglu, C. and Boynukahn, K. and Ugur, M. G. and Al, Ragıp Atakan and Kuzey, G. Mocan and Baykal, C.},
title = {Overexpression of c-Met in cervical intraepithelial neoplasia},
journal = {EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY},
year = {2012},
volume = {33},
number = {6},
pages = {625--628},
issn = {0392-2936},
url = {https://akademik.atauni.edu.tr/yayinlar/216457-overexpression-of-c-met-in-cervical-intraepithelial-neoplasia}
}