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Makale Tam Makale Uluslararası 2013

Preparation and characterization of metformin hydrochloride loaded-Eudragit (R) RSPO and Eudragit (R) RSPO/PLGA nanoparticles

Meltem Çetin, Alptuğ Atila, Selma Şahin, İmran Vural

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY Cilt 18 · Sayı 3 · ss. 570–576 · 01.05.2013
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Özet

The aim of the present study was to develop and characterize metformin HCl-loaded nanoparticle formulations. Nanoparticles were prepared by the nanoprecipitation method using both a single polymer (Eudragit (R) RSPO) and a polymer mixture (Eudragit/PLGA). The mean particle size ranged from 268.8 to 288 nm and the nanoparticle surface was positively charged (9.72 to 10.1 mV). The highest encapsulation efficiency was observed when Eudragit (R) RSPO was used. All formulations showed highly reproducible drug release profiles and the in vitro drug release in phosphate buffer (pH = 6.8) ranged from 92 to 100% in 12 h. These results suggest that Eudragit (R) RSPO or Eudragit/PLGA nanoparticles might represent a promising sustained-release oral formulation for metformin HCl, reducing the necessity of repeated administrations of high doses to maintain effective plasma concentrations, and thus, increasing patient compliance and reducing the incidence of side-effects.

Anahtar kelimeler

IN-VITRO RELEASE COMBINATION FORMULATION nanoparticles PLGA PLGA NANOPARTICLES Eudragit (R) RSPO DELIVERY MICROSPHERES metformin hydrochloride nanoprecipitation method polymer mixture DRUG ENTRAPMENT EFFICIENCY VIVO EVALUATION PARTICLE-SIZE

Atıf için künye

Çetin, M., Atila, A., Şahin, S., & Vural, İ. (2013). Preparation and characterization of metformin hydrochloride loaded-Eudragit (R) RSPO and Eudragit (R) RSPO/PLGA nanoparticles. PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, 18(3), 570–576. https://doi.org/10.3109/10837450.2011.604783

BibTeX 
@article{cetin2013-21549,
  author = {Çetin, Meltem and Atila, Alptuğ and Şahin, Selma and Vural, İmran},
  title = {Preparation and characterization of metformin hydrochloride loaded-Eudragit (R) RSPO and Eudragit (R) RSPO/PLGA nanoparticles},
  journal = {PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY},
  year = {2013},
  volume = {18},
  number = {3},
  pages = {570--576},
  issn = {1083-7450},
  doi = {10.3109/10837450.2011.604783},
  url = {https://akademik.atauni.edu.tr/yayinlar/21549-preparation-and-characterization-of-metformin-hydrochloride-loaded-eudragit-r}
}