Makale
Tam Makale
Uluslararası
2006
Treatment of malignant gliomas with mitoxantrone-loaded poly (lactide-co-glycolide) microspheres
NEUROSURGERY
Cilt 59 · Sayı 6 · ss. 1296–1302 · 01.12.2006
Özet
OBJECTIVE: Mitoxantrone (MTZ) has potent in vitro activity against malignant glioma cell lines, but it,cannot be used effectively as a systemic agent for the treatment of brain tumors because of its poor central nervous system penetration. However, MTZ-loaded poly(lactide-co-glycolide) (PLGA) microspheres may be injected into the peritumoral area and into tumor tissue to provide effective and sustained local drug concentrations without causing systemic side effects.
Anahtar kelimeler
IN-VITRO
MICROSPHERES
CONTROLLED-RELEASE
MALIGNANT GLIOMA
high-performance liquid chromatography
mitoxantrone
poly(lactide-co-glycolide)
rat glioma cells
RG2 cells
INJECTABLE CHEMOTHERAPEUTIC MICROSPHERES
SURVIVAL FOLLOWING IMPLANTATION
CULTURED MAMMALIAN-CELLS
BRAIN-TUMORS
DRUG-DELIVERY
BIODEGRADABLE MICROSPHERES
INTERSTITIAL CHEMOTHERAPY
ALBUMIN MICROSPHERES
Atıf için künye
Yemıscı, M., Bozdag, S., Çetin, M., Söylemezoglu, F., Capan, Y., Dalkara, T., & Vural, I. (2006). Treatment of malignant gliomas with mitoxantrone-loaded poly (lactide-co-glycolide) microspheres. NEUROSURGERY, 59(6), 1296–1302. https://doi.org/10.1227/01.neu.0000245607.99946.8f
BibTeX
@article{yemisci2006-21537,
author = {Yemıscı, M and Bozdag, S and Çetin, Meltem and Söylemezoglu, F and Capan, Y and Dalkara, T and Vural, I},
title = {Treatment of malignant gliomas with mitoxantrone-loaded poly (lactide-co-glycolide) microspheres},
journal = {NEUROSURGERY},
year = {2006},
volume = {59},
number = {6},
pages = {1296--1302},
issn = {0148-396X},
doi = {10.1227/01.neu.0000245607.99946.8f},
url = {https://akademik.atauni.edu.tr/yayinlar/21537-treatment-of-malignant-gliomas-with-mitoxantrone-loaded-poly-lactide-co}
}