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Makale Tam Makale Uluslararası 2010

Preparation and characterization of anticancer drug-loaded implantable PLGA microparticles

Meltem Çetin, İmran Vural, Alptuğ Atila, Yucel Kadıoglu

TURKISH JOURNAL OF CHEMISTRY Cilt 34 · ss. 509–516 · 01.08.2010
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Özet

This article describes the preparation and characterization of anticancer drug-loaded poly(lactide-co-glycolide) (PLGA) microparticles. PLGA microparticles loaded with doxorubicin HCl (DOX) were prepared via o/w emulsion solvent evaporation. The release characteristics, encapsulation efficiency, size, and morphology of the PLGA microparticles were also determined. A cytotoxicity test was performed by using Glioma RG2 cancer cells to investigate the cytotoxicity of DOX-loaded PLGA microparticles. The DOX-loaded PLGA microparticles had an average diameter of 500 +/- 9 nm. The DOX encapsulation efficiency and drug loading were 22.75% and 0.78%, respectively. DOX-loaded PLGA microparticles displayed a significant cytotoxicity toward the RG2 cells as compared to the unloaded PLGA microparticles.

Anahtar kelimeler

IN-VITRO CYCLOSPORINE-A DOXORUBICIN PLGA BLOOD-BRAIN-BARRIER RG2 cell line microparticles POLY(BUTYL CYANOACRYLATE) NANOPARTICLES CENTRAL-NERVOUS-SYSTEM GUIDED FOCUSED ULTRASOUND LOCAL-DELIVERY CONTROLLED-RELEASE ENHANCED DELIVERY MALIGNANT GLIOMA

Sürdürülebilir Kalkınma Amaçları

  • SKA 3: Sağlıklı Bireyler

Atıf için künye

Çetin, M., Vural, İ., Atila, A., & Kadıoglu, Y. (2010). Preparation and characterization of anticancer drug-loaded implantable PLGA microparticles. TURKISH JOURNAL OF CHEMISTRY, 34, 509–516. https://doi.org/10.3906/kim-0910-237

BibTeX 
@article{cetin2010-21533,
  author = {Çetin, Meltem and Vural, İmran and Atila, Alptuğ and Kadıoglu, Yucel},
  title = {Preparation and characterization of anticancer drug-loaded implantable PLGA microparticles},
  journal = {TURKISH JOURNAL OF CHEMISTRY},
  year = {2010},
  volume = {34},
  pages = {509--516},
  issn = {1300-0527},
  doi = {10.3906/kim-0910-237},
  url = {https://akademik.atauni.edu.tr/yayinlar/21533-preparation-and-characterization-of-anticancer-drug-loaded-implantable-plga}
}