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Makale Tam Makale Uluslararası 2015

Comparative Investigation of Protective Effects of Metyrosine and Metoprolol Against Ketamine Cardiotoxicity in Rats

Ali Ahıskalıoğlu, İlker İnce, Mehmet Aksoy, Elif Oral Ahiskalioglu, Mehmet Çömez, Ayşenur Dostbil, Mine Çelik, Hamit Hakan Alp, Resit Coşkun, Alı Taghızadehghalehjoughı, Bahadir Suleyman

Cardiovascular Toxicology Cilt 15 · ss. 336–344 · 01.10.2015
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Özet

This study investigated the effect of metyrosine against ketamine-induced cardiotoxicity in rats and compared the results with the effect of metoprolol. In this study, rats were divided into groups A, B and C. In group A, we investigated the effects of a single dose of metyrosine (150 mg/kg) and metoprolol (20 mg/kg) on single dose ketamine (60 mg/kg)-induced cardiotoxicity. In group B, we investigated the effect of metyrosine and metoprolol, which were given together with ketamine for 30 days. In group C, we investigated the effect of metyrosine and metoprolol given 15 days before ketamine and 30 days together with ketamine on ketamine cardiotoxicity. By the end of this process, we evaluated the effects of the levels of oxidant-antioxidant parameters such as MDA, MPO, 8-OHGua, tGSH, and SOD in addition to CK-MB and TP I on cardiotoxicity in rat heart tissue. The experimental results show that metyrosine prevented ketamine cardiotoxicity in groups A, B and C and metoprolol prevented it in only group C.

Anahtar kelimeler

TISSUE ACID oxidative DNA damage ASSAY antioxidant Rat CHROMATOGRAPHY 8-OXOGUANINE metyrosine oxidant cisplatin BASES Metoprolol Cardiotoxicity KETAMINE BLOCKERS

Atıf için künye

Ahıskalıoğlu, A., İnce, İ., Aksoy, M., Ahiskalioglu, E. O., Çömez, M., Dostbil, A., Çelik, M., Alp, H. H., Coşkun, R., Taghızadehghalehjoughı, A., & Suleyman, B. (2015). Comparative Investigation of Protective Effects of Metyrosine and Metoprolol Against Ketamine Cardiotoxicity in Rats. Cardiovascular Toxicology, 15, 336–344. https://doi.org/10.1007/s12012-014-9301-z

BibTeX 
@article{ahiskalioglu2015-211842,
  author = {Ahıskalıoğlu, Ali and İnce, İlker and Aksoy, Mehmet and Ahiskalioglu, Elif Oral and Çömez, Mehmet and Dostbil, Ayşenur and Çelik, Mine and Alp, Hamit Hakan and Coşkun, Resit and Taghızadehghalehjoughı, Alı and Suleyman, Bahadir},
  title = {Comparative Investigation of Protective Effects of Metyrosine and Metoprolol Against Ketamine Cardiotoxicity in Rats},
  journal = {Cardiovascular Toxicology},
  year = {2015},
  volume = {15},
  pages = {336--344},
  issn = {1530-7905},
  doi = {10.1007/s12012-014-9301-z},
  url = {https://akademik.atauni.edu.tr/yayinlar/211842-comparative-investigation-of-protective-effects-of-metyrosine-and-metoprolol}
}