Comparison Of The Efficacy Of Dexmedetomidine And Dexmedetomidine-Magnesium Combination In Sedation Management In Intensive Care

Objective<br style="color: rgb(33, 37, 41); font-family: -apple-system, BlinkMacSystemFont, "Segoe UI", Roboto, "Helvetica Neue", Arial, "Noto Sans", sans-serif, "Apple Color Emoji", "Segoe UI Emoji", "Segoe UI Symbol", "Noto Color Emoji"; font-size: 14.4px;">The aim of this study was to evaluate the correlation of sedation with subjective clinical sedation scores and compare plasma cortisol levels as an objective marker between two groups: patients sedated with dexmedetomidine alone and patients sedated with a combination of dexmedetomidine and magnesium, in mechanically ventilated patients.<br style="color: rgb(33, 37, 41); font-family: -apple-system, BlinkMacSystemFont, "Segoe UI", Roboto, "Helvetica Neue", Arial, "Noto Sans", sans-serif, "Apple Color Emoji", "Segoe UI Emoji", "Segoe UI Symbol", "Noto Color Emoji"; font-size: 14.4px;">Materials and Methods<br style="color: rgb(33, 37, 41); font-family: -apple-system, BlinkMacSystemFont, "Segoe UI", Roboto, "Helvetica Neue", Arial, "Noto Sans", sans-serif, "Apple Color Emoji", "Segoe UI Emoji", "Segoe UI Symbol", "Noto Color Emoji"; font-size: 14.4px;">A total of 50 patients were enrolled and divided into two groups. Group 1(dexmedetomidine group) received a loading dose of 1μg/kg, followed by a continuous infusion of 0.2-1.4 μg/kg/hour for 24 hours. Group 2(dexmedetomidine+magnesium group) received a loading dose of 1 μg/kg of dexmedetomidine, followed by a continuous infusion of 0.2-1.4 μg/kg/hour for 24 hours, along with two bolus doses of 2 grams of magnesium and a continuous infusion of 16mg/24 hours. Sedation scale scores, Glasgow coma scores, heart rate, and plasma cortisol levels at baseline and at 24 hours were recorded throughout the 24-hour study period.<br style="color: rgb(33, 37, 41); font-family: -apple-system, BlinkMacSystemFont, "Segoe UI", Roboto, "Helvetica Neue", Arial, "Noto Sans", sans-serif, "Apple Color Emoji", "Segoe UI Emoji", "Segoe UI Symbol", "Noto Color Emoji"; font-size: 14.4px;">Results<br style="color: rgb(33, 37, 41); font-family: -apple-system, BlinkMacSystemFont, "Segoe UI", Roboto, "Helvetica Neue", Arial, "Noto Sans", sans-serif, "Apple Color Emoji", "Segoe UI Emoji", "Segoe UI Symbol", "Noto Color Emoji"; font-size: 14.4px;">At 24 hours, cortisol levels were significantly lower in Group 2(p < 0.05). Heart rate was significantly lower in Group 2, except at baseline(p < 0.05). No significant differences between the groups regarding sedation scale scores or Glasgow coma scores(p > 0.05) were found.<br style="color: rgb(33, 37, 41); font-family: -apple-system, BlinkMacSystemFont, "Segoe UI", Roboto, "Helvetica Neue", Arial, "Noto Sans", sans-serif, "Apple Color Emoji", "Segoe UI Emoji", "Segoe UI Symbol", "Noto Color Emoji"; font-size: 14.4px;">Conclusion<br style="color: rgb(33, 37, 41); font-family: -apple-system, BlinkMacSystemFont, "Segoe UI", Roboto, "Helvetica Neue", Arial, "Noto Sans", sans-serif, "Apple Color Emoji", "Segoe UI Emoji", "Segoe UI Symbol", "Noto Color Emoji"; font-size: 14.4px;">Although adding magnesium to dexmedetomidine provided sufficient sedation and may have enhanced compliance with mechanical ventilation, no statistically significant difference was observed in achieving the target sedation levels in a clinical setting.<br style="color: rgb(33, 37, 41); font-family: -apple-system, BlinkMacSystemFont, "Segoe UI", Roboto, "Helvetica Neue", Arial, "Noto Sans", sans-serif, "Apple Color Emoji", "Segoe UI Emoji", "Segoe UI Symbol", "Noto Color Emoji"; font-size: 14.4px;">