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Makale Tam Makale Uluslararası 2025

Therapeutic Potential of Irisin in Ovarian Torsion-Detorsion: Mitigating Oxidative Stress and Inflammatory Response

Mustafa Can Güler, Burak Bircan, Ersen Eraslan, Fazile Nur Ekinci Akdemir, Şahin Yazıcı, Derya Güzel Erdoğan, Deniz Öztürk, Elif Polat, Ayhan Tanyeli

CLINICAL AND EXPERIMENTAL HEALTH SCIENCES Cilt 15 · Sayı 2 · ss. 434–439 · 01.01.2025
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Özet

Objective: Ovarian torsion (OT) is a critical gynecological emergency marked by partial or complete rotation of the ovary around its ligamentous supports, resulting in impaired blood flow and potential ischemic injury or necrosis if not treated promptly. This study explores the potential of irisin in mitigating ischemia-reperfusion (I/R) injury following ovarian torsion-detorsion (T/D), with a focus on oxidative stress and inflammatory mediators.

Methods: Twenty-four female Sprague-Dawley rats were allocated into three groups: Sham, T/D, and irisin 10 mu g/kg. Oxidative stress markers-total oxidant status (TOS), oxidative stress index (OSI), malondialdehyde (MDA), and myeloperoxidase (MPO)-were measured to assess tissue damage. Antioxidant parameters, including superoxide dismutase (SOD) activity and total antioxidant status (TAS) were evaluated. Serum levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) were analyzed to assess systemic inflammation and irisin's modulatory role.

Results: The T/D group showed elevated MPO and MDA levels relative to the sham group (p<.05), alongside significant reductions in SOD activity and TAS levels (p<.05). Irisin administration reversed these imbalances, decreasing MPO and MDA levels and enhancing SOD and TAS levels (p<.05 vs. T/D group). TNF-alpha and IL-1 beta levels, which were significantly elevated in the T/D group, were reduced by irisin treatment (p < .05 vs. T/D group), indicating its anti-inflammatory efficacy.

Conclusion: The findings support the potential of irisin as a therapeutic agent for mitigating oxidative stress and inflammation in ovarian I/R injury. Irisin may offer clinical benefits in preserving ovarian function during conditions related to T/D.

Sürdürülebilir Kalkınma Amaçları

  • SKA 3: Sağlıklı Bireyler

Atıf için künye

Güler, M. C., Bircan, B., Eraslan, E., Ekinci Akdemir, F. N., Yazıcı, Ş., Güzel Erdoğan, D., Öztürk, D., Polat, E., & Tanyeli, A. (2025). Therapeutic Potential of Irisin in Ovarian Torsion-Detorsion: Mitigating Oxidative Stress and Inflammatory Response. CLINICAL AND EXPERIMENTAL HEALTH SCIENCES, 15(2), 434–439. https://doi.org/10.33808/clinexphealthsci.1636484

BibTeX 
@article{guler2025-210256,
  author = {Güler, Mustafa Can and Bircan, Burak and Eraslan, Ersen and Ekinci Akdemir, Fazile Nur and Yazıcı, Şahin and Güzel Erdoğan, Derya and Öztürk, Deniz and Polat, Elif and Tanyeli, Ayhan},
  title = {Therapeutic Potential of Irisin in Ovarian Torsion-Detorsion: Mitigating Oxidative Stress and Inflammatory Response},
  journal = {CLINICAL AND EXPERIMENTAL HEALTH SCIENCES},
  year = {2025},
  volume = {15},
  number = {2},
  pages = {434--439},
  issn = {2459-1459},
  doi = {10.33808/clinexphealthsci.1636484},
  url = {https://akademik.atauni.edu.tr/yayinlar/210256-therapeutic-potential-of-irisin-in-ovarian-torsion-detorsion-mitigating}
}