Investigation of the Curative Effect of Urapidil on Intestinal Inflammation and Oxidative Damage: An Experimental Study
Özet
The antioxidant effects of urapidil were investigated histopathologically and biochemically on the intestinal tissue that underwent ischemia-reperfusion injury. 40 Wistar albino female rats were divided into sham operation (Group 1), ischemia-reperfusion (Group 2), ischemia-reperfusion plus dimethyl sulfoxide (Group 3), ischemia-reperfusion plus urapidil 0,5 mg/kg (Group 4), and ischemia-reperfusion plus urapidil 5 mg/kg (Group 5). All rats except group 1 had 1h ischemia followed by 2h reperfusion to investigate the effects of urapidil through TAS, TOS, MDA, MPO, SOD, NF-κB, caspase-3, and LC3B. In terms of immunohistochemical staining with caspase 3, NF-κB and LC3B there was a statistical difference in group 1 compared with other groups (p <0.05). A statistically significant difference of MDA levels was only found between the treatment groups (groups 4 & 5) and Group 3. We suggest that urapidil decreases the oxidative damage in ischemia-reperfusion injury on the intestinal tissue of rats as a probable antioxidant.
Atıf için künye
Tanyeli, A., Güzel Erdoğan, D., Öztürk, D., Çomaklı, S., Baylan, H., & Polat, E. (2020). Investigation of the Curative Effect of Urapidil on Intestinal Inflammation and Oxidative Damage: An Experimental Study. International of Academic Medicine and Pharmacy, 2(2), 66–71. https://doi.org/10.29228/jamp.42853
BibTeX
@article{tanyeli2020-210230,
author = {Tanyeli, Ayhan and Güzel Erdoğan, Derya and Öztürk, Deniz and Çomaklı, Selim and Baylan, Hüseyin and Polat, Elif},
title = {Investigation of the Curative Effect of Urapidil on Intestinal Inflammation and Oxidative Damage: An Experimental Study},
journal = {International of Academic Medicine and Pharmacy},
year = {2020},
volume = {2},
number = {2},
pages = {66--71},
issn = {2687-5365},
doi = {10.29228/jamp.42853},
url = {https://akademik.atauni.edu.tr/yayinlar/210230-investigation-of-the-curative-effect-of-urapidil-on-intestinal-inflammation-and}
}