Costunolide, an effective agent against oxidative damage, apoptosis and autophagy in the ovarian torsion/detorsion model

Armin Akış, Pakistan; Tanyeli, Ayhan; Ekinci Akdemir, Fazile Nur; Güler, Mustafa Can; Şebin, Saime Özbek; Eraslan, Ersen; Laloğlu, Esra; Çomaklı, Selim

doi:10.1080/13813455.2024.2407548

Makale Tam Makale Uluslararası 2025

Costunolide, an effective agent against oxidative damage, apoptosis and autophagy in the ovarian torsion/detorsion model

Pakistan Armin Akış, Ayhan Tanyeli, Fazile Nur Ekinci Akdemir, Mustafa Can Güler, Saime Özbek Şebin, Ersen Eraslan, Esra Laloğlu, Selim Çomaklı

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY Cilt 131 · Sayı 2 · ss. 265–273 · 01.03.2025

DOI ile aç

Özet

AimThis study assessed the efficacy of costunolide (COST) against oxidative tissue damage in the ovarian torsion/detorsion (TD) model.MethodologyAnimals were randomly assigned to sham, ovarian TD, COST 5 mg/kg + ovarian TD, and COST 10 mg/kg + ovarian TD groups. COST's effectiveness was determined by assessing oxidative stress markers, interleukin levels, and histopathological examinations.ResultsOxidative stress markers were elevated in the ovarian TD group compared to the sham group. COST treatment represented a decline compared to the TD group. Besides, the antioxidant activity was significantly higher in the ovarian TD group than in the sham group. COST treatment improved the antioxidant parameters compared to the TD group. Inflammatory parameters, such as tumour necrosis factor- alpha (TNF-alpha) and interleukin 1-beta (IL-1 beta) were higher in the ovarian TD group than the sham group.ConclusionCOST treatment suppressed the proinflammatory cytokine expression compared to the TD group. Histopathological data supported these findings.

Anahtar kelimeler

Costunolide ovarian torsion/detorsion oxidative tissue damage

Sürdürülebilir Kalkınma Amaçları

SKA 3: Sağlıklı Bireyler

Atıf için künye

Armin Akış, P., Tanyeli, A., Ekinci Akdemir, F. N., Güler, M. C., Şebin, S. Ö., Eraslan, E., Laloğlu, E., & Çomaklı, S. (2025). Costunolide, an effective agent against oxidative damage, apoptosis and autophagy in the ovarian torsion/detorsion model. ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY, 131(2), 265–273. https://doi.org/10.1080/13813455.2024.2407548

BibTeX

@article{arminakis2025-210192,
  author = {Armin Akış, Pakistan and Tanyeli, Ayhan and Ekinci Akdemir, Fazile Nur and Güler, Mustafa Can and Şebin, Saime Özbek and Eraslan, Ersen and Laloğlu, Esra and Çomaklı, Selim},
  title = {Costunolide, an effective agent against oxidative damage, apoptosis and autophagy in the ovarian torsion/detorsion model},
  journal = {ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY},
  year = {2025},
  volume = {131},
  number = {2},
  pages = {265--273},
  issn = {1381-3455},
  doi = {10.1080/13813455.2024.2407548},
  url = {https://akademik.atauni.edu.tr/yayinlar/210192-costunolide-an-effective-agent-against-oxidative-damage-apoptosis-and-autophagy}
}