The protective effects of hesperidin pretreatment on kidney and remote organs against renal ischemia-reperfusion injury
Özet
OBJECTIVE: As an antioxidant and anti-inflammatory agent, Hesperidin was in-vestigated to prove whether it prevents damage to the kidney and lung tissues of rats undergo-ing renal ischemia-reperfusion injury.MATERIALS AND METHODS: Four groups of rats were set, including eight subjects each as Group 1 (control), Group 2-RIR (renal isch-emia reperfusion), Groups 3 and 4 as pretreat-ment groups (50 HES, 100 HES).RESULTS: According to our results, Hesperi-din pretreatment improved the biochemical and histopathological parameters in kidney and lung tissues of rats with ischemia-reperfusion injury. Besides, a 100 mg/kg dose of Hesperidin was found to be more beneficial to the rats than 50 mg/kg.CONCLUSIONS: The study suggests that Hesperidin is protective against renal and lung tissues of rats that underwent ischemia-reper-fusion injury.
Anahtar kelimeler
Atıf için künye
Karacaer, C., Erdogan, D. G., Tanyeli, A., Baylan, H., ERASLAN, E., Güler, M. C., Polat, E., & Çomaklı, S. (2023). The protective effects of hesperidin pretreatment on kidney and remote organs against renal ischemia-reperfusion injury. EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 27(7), 2808–2814. https://doi.org/10.26355/eurrev_202304_31911
BibTeX
@article{karacaer2023-210191,
author = {Karacaer, C. and Erdogan, D. G. and Tanyeli, Ayhan and Baylan, H. and ERASLAN, ERSEN and Güler, Mustafa Can and Polat, E. and Çomaklı, Selim},
title = {The protective effects of hesperidin pretreatment on kidney and remote organs against renal ischemia-reperfusion injury},
journal = {EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES},
year = {2023},
volume = {27},
number = {7},
pages = {2808--2814},
issn = {1128-3602},
doi = {10.26355/eurrev_202304_31911},
url = {https://akademik.atauni.edu.tr/yayinlar/210191-the-protective-effects-of-hesperidin-pretreatment-on-kidney-and-remote-organs}
}