Long-term outcomes of ablative polymerization with cyanoacrylate glue in the treatment of refluxing saphenous veins: A single center prospective observational study

BACKGROUND AND AIM:The use of CAA

in the treatment of refluxing saphenous veins has increased in the last decade,

and its effectiveness and safety have been proven by many studies. The

objective of this single center prospective observational study is to evaluate

the 5-year results of cyanoacrylate ablation (CAA) method in venous

insufficiency.<o:p></o:p>

METHODS:There were 210 subjects

were treated with the CAA between April 2014 and June 2016. The protocol included

physical and colour Doppler ultrasonography examination, venous clinical

severity score and quality of life assessment before and after the procedure.

The primary endpoint was treated veins closure rates and the secondary endpoint

was clinical improvement.<o:p></o:p>

RESULTS:In total, 236 ablation

procedures were successfully completed on 210 subjects. 136 (64.8%) of them

completed the 5-year follow-up visits. The mean follow-up period was 76 months.

The treated saphenous vens complete closure rate were 92.1% at five-year.

Various interventions were performed for varicose veins in 12(8.8%) patients

during their follow-up from 3rd month to 5th year. Although clinical and

quality of life improvement was slowed compared to previous follow-ups, they

were significantly increased compared to baseline values. Device or

procedure-related late side effects were not observed during the long-term

period.<o:p></o:p>

CONCLUSIONS:This study

demonstrated that long-term efficacy and safety of CAA in the treatment of

refluxing saphenous veins with high closure rates and significant clinical and

quality of life improvement. We think that the long-term results of many

studies will support this results.<o:p></o:p>

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Keywords: Cyanoacrylate ablation<o:p></o:p>