Evaluation of preoperative ACE inhibitors for renal protection in cardiac surgery.
Özet
Abstract
Background: There are many causes of acute kidney injury after cardiac surgery. Activation of the renin-angiotensin system is
one of the most important mechanisms. In this article, we investigated the effect of angiotensin-converting enzyme (ACE) inhibitor
treatment on renal damage in cardiac surgery.
Methods: Six hundred twelve patients undergoing cardiac surgery were divided into 2 groups. The patients in group I were 319
patients who used ACE inhibitors before the operation. The patients in Group II consisted of 293 patients who did not use ACE
inhibitors. In addition to blood renal parameters and the need for dialysis, length of hospital stay, hospital costs, and readmission
rates were evaluated between the 2 groups. In addition to the early-term results, the patients were followed for 2 years for renal
destruction.
Results: Dialysis was needed in 9 patients in Group I. Hemodialysis was required in 31 of the Group II patients. In addition, the
increase in creatinine and blood urea nitrogen levels and the decrease in glomerular filtration rate and creatinine clearance were
higher in Group II patients (P <.05). The length of stay in the intensive care unit and hospitalization were statistically significantly
higher in Group II patients. In addition, hospital costs and re-hospitalizations were statistically significantly lower in the treatment
group.
Conclusion: The use of ACE inhibitors before cardiac surgery is effective in preserving renal function in the postoperative
period, and these results are important in achieving acceptable and favorable outcomes for patients and the hospital in the
postoperative period.
Abbreviations: ACE = angiotensin-converting enzyme, AKI = acute kidney injury, AKIN = AKI network, BUN = blood nitrogen
urea, CABG = coronary artery bypass graft, CPB = cardiopulmonary bypass, Cr = creatinine, CrCL = creatinine clearance, ECMO =
extracorporeal membrane oxygenation, IABP = intra-aortic balloon pump, ICU = intensive care unit, IMA = internal mammarian
artery, KDIGO = kidney disease improving global outcomes, RIFLE = risk, injury, failure, loss, and end-stage renal disease.
Anahtar kelimeler
Atıf için künye
Kilic, Y., Jalalzaı, I., Sonmez, E., & Erkut, B. (2026). Evaluation of preoperative ACE inhibitors for renal protection in cardiac surgery. MEDICINE, 105(13). https://doi.org/10.1097/md.0000000000037760
BibTeX
@article{kilic2026-210122,
author = {Kilic, Yasin and Jalalzaı, Izatullah and Sonmez, Ebubekir and Erkut, Bilgehan},
title = {Evaluation of preoperative ACE inhibitors for renal protection in cardiac surgery.},
journal = {MEDICINE},
year = {2026},
volume = {105},
number = {13},
issn = {0025-7974},
doi = {10.1097/md.0000000000037760},
url = {https://akademik.atauni.edu.tr/yayinlar/210122-evaluation-of-preoperative-ace-inhibitors-for-renal-protection-in-cardiac}
}