Morphological Reconstruction of a Critical-Sized Bone Defect in the Maxillofacial Region Using Modified Chitosan in Rats with Sub-Compensated Type I Diabetes Mellitus

Patlataya, Nadezhda N.; Bolshakov, Igor N.; Khorzhevskii, Vladimir A.; Levenets, Anatoli A.; Medvedeva, Nadezhda N.; Cherkashina, Mariya A.; Nikolaenko, Matvey M.; Ryaboshapko, Ekaterina I.; Dmitrienko, Anna E.; Gooneratne, Ravi; Marin, Luminita; Hassıbelnaby, Abdelaty Mostafa Abdelaty; Ju, Xianghong

doi:10.3390/polym15214337

Makale Tam Makale Uluslararası 2023

Morphological Reconstruction of a Critical-Sized Bone Defect in the Maxillofacial Region Using Modified Chitosan in Rats with Sub-Compensated Type I Diabetes Mellitus

Nadezhda N. Patlataya, Igor N. Bolshakov, Vladimir A. Khorzhevskii, Anatoli A. Levenets, Nadezhda N. Medvedeva, Mariya A. Cherkashina, Matvey M. Nikolaenko, Ekaterina I. Ryaboshapko, Anna E. Dmitrienko, Ravi Gooneratne, Luminita Marin, Abdelaty Mostafa Abdelaty Hassıbelnaby, Xianghong Ju

Polymers Cilt 15 · Sayı 21 · 01.11.2023

DOI ile aç

Özet

It is known that complexes based on natural polysaccharides are able to eliminate bone defects. Prolonged hyperglycemia leads to low bone regeneration and a chronic inflammatory response. The purpose of this study was to increase the efficiency of early bone formation in a cavity of critical size in diabetes mellitus in the experiment. The polyelectrolyte complex contains high-molecular ascorbate of chitosan, chondroitin sulfate, sodium hyaluronate, heparin, adgelon serum growth factor, sodium alginate and amorphous nanohydroxyapatite (CH-SA-HA). Studies were conducted on five groups of white female Wistar rats: group 1-regeneration of a bone defect in healthy animals under a blood clot; group 2-regeneration of a bone defect under a blood clot in animals with diabetes mellitus; group 3-bone regeneration in animals with diabetes mellitus after filling the bone cavity with a collagen sponge; group 4-filling of a bone defect with a CH-SA-HA construct in healthy animals; group 5-filling of a bone defect with a CH-SA-HA construct in animals with diabetes mellitus. Implantation of the CH-SA-HA construct into bone cavities in type I diabetic rats can accelerate the rate of bone tissue repair. The inclusion of modifying polysaccharides and apatite agents in the construction may be a prospect for further improvement of the properties of implants.

Sürdürülebilir Kalkınma Amaçları

SKA 3: Sağlıklı Bireyler

Atıf için künye

Patlataya, N. N., Bolshakov, I. N., Khorzhevskii, V. A., Levenets, A. A., Medvedeva, N. N., Cherkashina, M. A., Nikolaenko, M. M., Ryaboshapko, E. I., Dmitrienko, A. E., Gooneratne, R., Marin, L., Hassıbelnaby, A. M. A., & Ju, X. (2023). Morphological Reconstruction of a Critical-Sized Bone Defect in the Maxillofacial Region Using Modified Chitosan in Rats with Sub-Compensated Type I Diabetes Mellitus. Polymers, 15(21). https://doi.org/10.3390/polym15214337

BibTeX

@article{patlataya2023-209998,
  author = {Patlataya, Nadezhda N. and Bolshakov, Igor N. and Khorzhevskii, Vladimir A. and Levenets, Anatoli A. and Medvedeva, Nadezhda N. and Cherkashina, Mariya A. and Nikolaenko, Matvey M. and Ryaboshapko, Ekaterina I. and Dmitrienko, Anna E. and Gooneratne, Ravi and Marin, Luminita and Hassıbelnaby, Abdelaty Mostafa Abdelaty and Ju, Xianghong},
  title = {Morphological Reconstruction of a Critical-Sized Bone Defect in the Maxillofacial Region Using Modified Chitosan in Rats with Sub-Compensated Type I Diabetes Mellitus},
  journal = {Polymers},
  year = {2023},
  volume = {15},
  number = {21},
  issn = {2073-4360},
  doi = {10.3390/polym15214337},
  url = {https://akademik.atauni.edu.tr/yayinlar/209998-morphological-reconstruction-of-a-critical-sized-bone-defect-in-the}
}