Enhanced stability of stilbene-glycoside-loaded nanoparticles coated with carboxymethyl chitosan and chitosan hydrochloride

Liu, Shiqi; Yang, Qianyu; Zhang, Jing; Yang, Mengnan; Wang, Yanhui; Sun, Ting; Ma, Chao; Hassıbelnaby, Abdelaty Mostafa Abdelaty

doi:10.1016/j.foodchem.2021.131343

Makale Tam Makale Uluslararası 2022

Enhanced stability of stilbene-glycoside-loaded nanoparticles coated with carboxymethyl chitosan and chitosan hydrochloride

Shiqi Liu, Qianyu Yang, Jing Zhang, Mengnan Yang, Yanhui Wang, Ting Sun, Chao Ma, Abdelaty Mostafa Abdelaty Hassıbelnaby

FOOD CHEMISTRY Cilt 372 · 15.03.2022

DOI ile aç

Özet

© 2021 Elsevier LtdStilbene-glycoside (THSG) is a promising dietary supplement with remarkable biological properties, however, its poor stability and low oral bioavailability hinder its application as an ingredient in functional foods. Herein, stilbene-glycoside-loaded nanoparticles (THSG-NPs) coated with carboxymethyl chitosan (CMC) and chitosan hydrochloride (CHC) using a complex coacervation method were successfully prepared for enhancing the stability of THSG. The optimized preparation parameters were 2.5 mg/mL CMC, 1.0 mg/mL CHC, 1.5 mg/mL THSG and preparation temperature of 25 °C, under which the experimentally designed particles averaged 381.9 nm with encapsulation efficiency (EE) of 68.6%. Solid-state characterization was assessed by Fourier transform infrared spectroscope and Differential scanning calorimetry. THSG-NPs showed significant protective effects against heat and solar radiation and exhibited remarkable pH-dependent and controlled release. This work demonstrated that enhanced stability and delayed release of THSG could be achieved using THSG-NPs, which could contribute to its potential application in the functional foods industry.

Anahtar kelimeler

STABILITY IMPACT PH ANTIOXIDANT ACTIVITY MECHANISM ALGINATE ENCAPSULATION FABRICATION ANTHOCYANINS Carboxymethyl chitosan Stilbene-glycoside Chitosan hydrochloride Complex coacervation

Atıf için künye

Liu, S., Yang, Q., Zhang, J., Yang, M., Wang, Y., Sun, T., Ma, C., & Hassıbelnaby, A. M. A. (2022). Enhanced stability of stilbene-glycoside-loaded nanoparticles coated with carboxymethyl chitosan and chitosan hydrochloride. FOOD CHEMISTRY, 372. https://doi.org/10.1016/j.foodchem.2021.131343

BibTeX

@article{liu2022-209983,
  author = {Liu, Shiqi and Yang, Qianyu and Zhang, Jing and Yang, Mengnan and Wang, Yanhui and Sun, Ting and Ma, Chao and Hassıbelnaby, Abdelaty Mostafa Abdelaty},
  title = {Enhanced stability of stilbene-glycoside-loaded nanoparticles coated with carboxymethyl chitosan and chitosan hydrochloride},
  journal = {FOOD CHEMISTRY},
  year = {2022},
  volume = {372},
  issn = {0308-8146},
  doi = {10.1016/j.foodchem.2021.131343},
  url = {https://akademik.atauni.edu.tr/yayinlar/209983-enhanced-stability-of-stilbene-glycoside-loaded-nanoparticles-coated-with}
}