Stachydrine alleviates lipid-induced skeletal muscle insulin resistance via AMPK/HO-1-mediated suppression of inflammation and endoplasmic reticulum stress

Jung, T. W.; Kim, H.; Park, S. Y.; Cho, W.; Oh, H.; Lee, H. J.; Hassıbelnaby, Abdelaty Mostafa Abdelaty; Hacımüftüoğlu, Ahmet; Jeong, J. H.

doi:10.1007/s40618-022-01866-8

Makale Tam Makale Uluslararası 2022

Stachydrine alleviates lipid-induced skeletal muscle insulin resistance via AMPK/HO-1-mediated suppression of inflammation and endoplasmic reticulum stress

T. W. Jung, H. Kim, S. Y. Park, W. Cho, H. Oh, H. J. Lee, Abdelaty Mostafa Abdelaty Hassıbelnaby, Ahmet Hacımüftüoğlu, J. H. Jeong

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION Cilt 45 · Sayı 11 · ss. 2181–2191 · 01.11.2022

DOI ile aç

Özet

Objective Insulin resistance develops due to skeletal muscle inflammation and endoplasmic reticulum (ER) stress. Stachydrine (STA), extracted from Leonurus heterophyllus, has been shown to suppress proliferation and induce apoptosis in breast cancer cells and exert anti-inflammatory properties in the brain, heart, and liver. However, the roles of STA in insulin signaling in skeletal muscle remain unclear. Herein, we examined the impacts of STA on insulin signaling in skeletal muscle under hyperlipidemic conditions and its related molecular mechanisms.

Anahtar kelimeler

SYSTEM PATHOGENESIS oxidative stress INFLAMMATION KAPPA-B liver ER stress PATHWAY Fibrosis INSULIN-RESISTANCE AMPK Heme oxygenase 1 ACTIVATED PROTEIN-KINASE HO-1. Stachydrine

Sürdürülebilir Kalkınma Amaçları

SKA 3: Sağlıklı Bireyler

Atıf için künye

Jung, T. W., Kim, H., Park, S. Y., Cho, W., Oh, H., Lee, H. J., Hassıbelnaby, A. M. A., Hacımüftüoğlu, A., & Jeong, J. H. (2022). Stachydrine alleviates lipid-induced skeletal muscle insulin resistance via AMPK/HO-1-mediated suppression of inflammation and endoplasmic reticulum stress. JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 45(11), 2181–2191. https://doi.org/10.1007/s40618-022-01866-8

BibTeX

@article{jung2022-209936,
  author = {Jung, T. W. and Kim, H. and Park, S. Y. and Cho, W. and Oh, H. and Lee, H. J. and Hassıbelnaby, Abdelaty Mostafa Abdelaty and Hacımüftüoğlu, Ahmet and Jeong, J. H.},
  title = {Stachydrine alleviates lipid-induced skeletal muscle insulin resistance via AMPK/HO-1-mediated suppression of inflammation and endoplasmic reticulum stress},
  journal = {JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION},
  year = {2022},
  volume = {45},
  number = {11},
  pages = {2181--2191},
  issn = {0391-4097},
  doi = {10.1007/s40618-022-01866-8},
  url = {https://akademik.atauni.edu.tr/yayinlar/209936-stachydrine-alleviates-lipid-induced-skeletal-muscle-insulin-resistance-via}
}