Pharmacokinetic properties of florfenicol in Egyptian Goats

The single-dose disposition kinetics of florfenicol was determined in healthy, non-lactating Egyptian goats, after its intravenous (iv) and intramuscular (im) administration at 20 mg kg-1 b.wt. Drug concentrations in serum and urine were determined using microbiological assay method and data was subjected to a kinetic analysis. Florfenicol concentrations in serum decreased in a bi-exponential manner after intravenous administration with distribution (t1/2α) and elimination (t1/2β) half-lives of 10.256 ± 0.938 and 56.237 ± 3.102 minute, respectively. The steady-state volume of distribution (Vdss) and total body clearance (Cltot) were 3.413 ± 0.304 l kg-1 and 3.306 ± 0.333 l kg h-1. After intramuscular administration, the peak serum concentration (Cmax) was 0.859 ± 0.025 μg ml-1, achieved at (Tmax) 1.220 + 0.045 h. Florfenicol was detected in urine up to 24 and 96 hour after iv and im administration, respectively. The extent of the protein bin-ding and systemic bioavailability of florfenicol were 22.45 ± 1.727% and 65.718 ± 3.372 %, respectively.