Gastroenteropancreatic neuroendocrine neoplasms: current development, challenges, and clinical perspectives
Özet
<jats:title>Abstract</jats:title><jats:p>Neuroendocrine neoplasms (NENs) are highly heterogeneous and potentially malignant tumors arising from secretory cells of the neuroendocrine system. Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are the most common subtype of NENs. Historically, GEP-NENs have been regarded as infrequent and slow-growing malignancies; however, recent data have demonstrated that the worldwide prevalence and incidence of GEP-NENs have increased exponentially over the last three decades. In addition, an increasing number of studies have proven that GEP-NENs result in a limited life expectancy. These findings suggested that the natural biology of GEP-NENs is more aggressive than commonly assumed. Therefore, there is an urgent need for advanced researches focusing on the diagnosis and management of patients with GEP-NENs. In this review, we have summarized the limitations and recent advancements in our comprehension of the epidemiology, clinical presentations, pathology, molecular biology, diagnosis, and treatment of GEP-NETs to identify factors contributing to delays in diagnosis and timely treatment of these patients.</jats:p>
Anahtar kelimeler
Atıf için künye
Zhang, X., Fan, Y., Jing, R., Getu, M. A., Chen, W., Zhang, W., Dong, H., Dakal, T. C., Hayat, A., Cai, H., Ashrafizadeh, M., Hassıbelnaby, A. M. A., Hacimuftuoglu, A., Liu, P., Li, T., Sethi, G., Ahn, K. S., Ertas, Y. N., Chen, M., … Gong, P. (2024). Gastroenteropancreatic neuroendocrine neoplasms: current development, challenges, and clinical perspectives. Military Medical Research, 11(1), 1–20. https://doi.org/10.1186/s40779-024-00535-6
BibTeX
@article{zhang2024-209730,
author = {Zhang, Xian-Bin and Fan, Yi-Bao and Jing, Rui and Getu, Mikiyas Amare and Chen, Wan-Ying and Zhang, Wei and Dong, Hong-Xia and Dakal, Tikam Chand and Hayat, Akhtar and Cai, Hua-Jun and Ashrafizadeh, Milad and Hassıbelnaby, Abdelaty Mostafa Abdelaty and Hacimuftuoglu, Ahmet and Liu, Peng and Li, Tian-Feng and Sethi, Gautam and Ahn, Kwang Seok and Ertas, Yavuz Nuri and Chen, Min-Jiang and Ji, Jian-Song and Ma, Li and Gong, Peng},
title = {Gastroenteropancreatic neuroendocrine neoplasms: current development, challenges, and clinical perspectives},
journal = {Military Medical Research},
year = {2024},
volume = {11},
number = {1},
pages = {1--20},
issn = {2095-7467},
doi = {10.1186/s40779-024-00535-6},
url = {https://akademik.atauni.edu.tr/yayinlar/209730-gastroenteropancreatic-neuroendocrine-neoplasms-current-development-challenges}
}