Design and preparation of multifunctional astaxanthin nanoparticles with good acid stability and hepatocyte-targeting ability for alcoholic liver injury alleviation
Özet
As a dietary nutrition supplement, astaxanthin (AXT) has attracted much attention in alleviating ethanol-induced liver injury due to its superior antioxidant ability. However, the poor water solubility and pH-vulnerable characteristics of AXT significantly restrict its application in nutrition intervention. In this study, multifunctional astaxanthin nanoparticles (LAD6:1@AXT) with good acid stability and hepatocyte-targeting ability were designed and prepared using 2-hydroxypropyl-β-cyclodextrin, lactobionic acid, and sodium alginate as raw materials. At pH 2.0, LAD6:1@AXT displayed a double reservation rate of the relative AXT content compared to free AXT. Significant antioxidative activity of LAD6:1@AXT was observed in cellular experiments. Ex vivo experiments revealed that the astaxanthin nanoparticles showed 90 % increased accumulation in the liver after oral administration for 24 h. A strong hepatic-targeting effect was found for LAD6:1@AXT, which could effectively ameliorate alcoholic liver injury. Our data indicated that the developed astaxanthin nanoparticles have the potential of nutrition intervention for alcohol-induced liver impairment.
Anahtar kelimeler
Atıf için künye
Hua, Z., Zhang, X., Xing, S., Li, J., Liang, D., Chen, Y., Hassıbelnaby, A. M. A., Zhu, B., Liu, D., & Tan, M. (2024). Design and preparation of multifunctional astaxanthin nanoparticles with good acid stability and hepatocyte-targeting ability for alcoholic liver injury alleviation. Materials Today Nano, 25. https://doi.org/10.1016/j.mtnano.2023.100436
BibTeX
@article{hua2024-209706,
author = {Hua, Zheng and Zhang, Xuedi and Xing, Shanghua and Li, Jiaxuan and Liang, Duo and Chen, Yannan and Hassıbelnaby, Abdelaty Mostafa Abdelaty and Zhu, Bei-Wei and Liu, Donghong and Tan, Mingqian},
title = {Design and preparation of multifunctional astaxanthin nanoparticles with good acid stability and hepatocyte-targeting ability for alcoholic liver injury alleviation},
journal = {Materials Today Nano},
year = {2024},
volume = {25},
issn = {2588-8420},
doi = {10.1016/j.mtnano.2023.100436},
url = {https://akademik.atauni.edu.tr/yayinlar/209706-design-and-preparation-of-multifunctional-astaxanthin-nanoparticles-with-good}
}