IL-38 alleviates atherogenic responses via SIRT6/HO-1 signaling: A promising strategy against obesity-related atherosclerosis
Özet
Interleukin-38 (IL-38), a member of the IL-1 family, is known for its anti-inflammatory properties mediated through ligand signaling in various disease models. It plays a significant role in atherosclerosis development, forming a theoretical basis for therapeutic strategies. However, the direct effects of IL-38 on atherogenic responses in the vascular endothelium and monocytes remain unclear. In this investigation, IL-38 treatment reduced THP-1 monocyte adhesion to HUVECs, decreased the expression of vascular adhesion molecules, and mitigated inflammation in the presence of palmitate. IL-38 treatment upregulated SIRT6 expression and enhanced autophagy markers such as LC3 conversion and p62 degradation. The effects of IL-38 were nullified by siRNA-mediated suppression of SIRT6 or heme oxygenase-1 (HO-1) in HUVECs and palmitate-treated THP-1 cells. These findings reveal that IL-38 mitigates inflammation through the SIRT6/HO-1 pathway, offering a potential therapeutic approach for addressing obesity-related atherosclerosis.
Anahtar kelimeler
Atıf için künye
Cho, W., Oh, H., Hassıbelnaby, A. M. A., Mobarak, E. H., Jeong, J. H., & Jung, T. W. (2024). IL-38 alleviates atherogenic responses via SIRT6/HO-1 signaling: A promising strategy against obesity-related atherosclerosis. Biochemical and Biophysical Research Communications, 694. https://doi.org/10.1016/j.bbrc.2023.149407
BibTeX
@article{cho2024-209651,
author = {Cho, Wonjun and Oh, Heeseung and Hassıbelnaby, Abdelaty Mostafa Abdelaty and Mobarak, Enas H. and Jeong, Ji Hoon and Jung, Tae Woo},
title = {IL-38 alleviates atherogenic responses via SIRT6/HO-1 signaling: A promising strategy against obesity-related atherosclerosis},
journal = {Biochemical and Biophysical Research Communications},
year = {2024},
volume = {694},
issn = {0006-291X},
doi = {10.1016/j.bbrc.2023.149407},
url = {https://akademik.atauni.edu.tr/yayinlar/209651-il-38-alleviates-atherogenic-responses-via-sirt6ho-1-signaling-a-promising}
}