Improved stability and aqueous solubility of β-carotene via encapsulation in self-assembled bioactive oleanolic acid nanoparticles

Liu, Shiqi; Zhang, Jing; Fu, Rao; Feng, Hao; Chu, Yibing; Huang, Dong; Liu, Han; Li, Chaonan; Ma, Chao; Hassıbelnaby, Abdelaty Mostafa Abdelaty

doi:10.1016/j.foodchem.2021.131498

Makale Tam Makale Uluslararası 2022

Improved stability and aqueous solubility of β-carotene via encapsulation in self-assembled bioactive oleanolic acid nanoparticles

Shiqi Liu, Jing Zhang, Rao Fu, Hao Feng, Yibing Chu, Dong Huang, Han Liu, Chaonan Li, Chao Ma, Abdelaty Mostafa Abdelaty Hassıbelnaby

FOOD CHEMISTRY Cilt 373 · 30.03.2022

DOI ile aç

Özet

© 2021 Elsevier LtdPoor water solubility and stability of β-carotene (Car) greatly hinder its application in foods. Herein, naturally occurring bioactive oleanolic acid (OA) was used as a nanocarrier to overcome these shortcomings by fabricating Car-loaded OA nanoparticles (Car/OA NPs). Through optimization, the encapsulation efficiency and loading capacity reached 80.7% and 32.6%, respectively. Systematic characterization suggested that Car was successfully encapsulated, and hydrogen bonding and hydrophobic interactions are the main forces facilitating the self-assembly and encapsulation. Compared with free Car, Car/OA NPs exhibited significantly improved water dispersibility and enhanced stability against UV radiation, heat, ionic strength, and acidic conditions. Further, Car/OA NPs provided gastric protection, delayed-release in simulated gastric fluid (SGF) and controlled release in simulated intestinal fluid (SIF). Additionally, both OA NPs and Car/OA NPs showed markedly inherent hepatoprotective effects. This work demonstrates that OA NPs can be used as inherent bioactive nanocarriers to deliver hydrophobic nutrients and bioactive food components.

Anahtar kelimeler

β-carotene Self-assembly hepatoprotective Oleanolic acid Nanocarrier 0-carotene

Atıf için künye

Liu, S., Zhang, J., Fu, R., Feng, H., Chu, Y., Huang, D., Liu, H., Li, C., Ma, C., & Hassıbelnaby, A. M. A. (2022). Improved stability and aqueous solubility of β-carotene via encapsulation in self-assembled bioactive oleanolic acid nanoparticles. FOOD CHEMISTRY, 373. https://doi.org/10.1016/j.foodchem.2021.131498

BibTeX

@article{liu2022-209595,
  author = {Liu, Shiqi and Zhang, Jing and Fu, Rao and Feng, Hao and Chu, Yibing and Huang, Dong and Liu, Han and Li, Chaonan and Ma, Chao and Hassıbelnaby, Abdelaty Mostafa Abdelaty},
  title = {Improved stability and aqueous solubility of β-carotene via encapsulation in self-assembled bioactive oleanolic acid nanoparticles},
  journal = {FOOD CHEMISTRY},
  year = {2022},
  volume = {373},
  issn = {0308-8146},
  doi = {10.1016/j.foodchem.2021.131498},
  url = {https://akademik.atauni.edu.tr/yayinlar/209595-improved-stability-and-aqueous-solubility-of-v-carotene-via-encapsulation-in}
}