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Tea Tree Oil Terpinen-4-ol Protects Gut Barrier Integrity by Upregulation of Tight Junction Proteins via the ERK1/2-Signaling Pathway

Yanhong Yong, Biao Fang, Yingxin Huang, Junyu Li, Tianyue Yu, Lianyun Wu, Canying Hu, Xiaoxi Liu, Zhichao Yu, Xingbin Ma, Ravi Gooneratne, Sidong Li, Abdelaty Mostafa Abdelaty Hassıbelnaby, Xianghong Ju

Frontiers in nutrition Cilt 8 · 27.01.2022
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Özet

Copyright © 2022 Yong, Fang, Huang, Li, Yu, Wu, Hu, Liu, Yu, Ma, Gooneratne, Li, Abd El-Aty and Ju.Tea tree oil (TTO) exhibits a potent antioxidant, antibacterial, and anti-inflammatory activity and is commonly used in skincare products. However, it is not clear whether TTO can protect gut barrier damage in inflammatory bowel disease (IBD) patients. Herein, we report the impact of terpinen-4-ol (TER, the primary constituent of TTO), on lipopolysaccharide (LPS)-induced intestinal epithelial cell barrier function impairment in intestinal porcine epithelial cell lines (IPEC-J2) and dextran sulfate sodium (DSS)-induced IBD in mice. TER protected against LPS-induced damage in IPEC-J2 cells in vitro and attenuated DSS-induced colitis in vivo. Added TER promoted the tight junction (TJ) proteins expressing in vitro and in vivo and attenuated the LPS-induced upregulation of ERK phosphorylation in IPEC-J2 cells. However, when an inhibitor of ERK phosphorylation was added, TER did not promote the expression of TJ protein, denoting that the ERK signaling pathway mediates the upregulation of TJ proteins. Our data may propose the potential application of TER in treating IBD.

Anahtar kelimeler

TERPINEN-4-OL Inflammatory bowel disease ERK1 2-signaling pathway tight junction (TJ) proteins mouse model ERK1/2-signaling pathway

Atıf için künye

Yong, Y., Fang, B., Huang, Y., Li, J., Yu, T., Wu, L., Hu, C., Liu, X., Yu, Z., Ma, X., Gooneratne, R., Li, S., Hassıbelnaby, A. M. A., & Ju, X. (2022). Tea Tree Oil Terpinen-4-ol Protects Gut Barrier Integrity by Upregulation of Tight Junction Proteins via the ERK1/2-Signaling Pathway. Frontiers in nutrition, 8. https://doi.org/10.3389/fnut.2021.805612

BibTeX 
@article{yong2022-209582,
  author = {Yong, Yanhong and Fang, Biao and Huang, Yingxin and Li, Junyu and Yu, Tianyue and Wu, Lianyun and Hu, Canying and Liu, Xiaoxi and Yu, Zhichao and Ma, Xingbin and Gooneratne, Ravi and Li, Sidong and Hassıbelnaby, Abdelaty Mostafa Abdelaty and Ju, Xianghong},
  title = {Tea Tree Oil Terpinen-4-ol Protects Gut Barrier Integrity by Upregulation of Tight Junction Proteins via the ERK1/2-Signaling Pathway},
  journal = {Frontiers in nutrition},
  year = {2022},
  volume = {8},
  issn = {2296-861X},
  doi = {10.3389/fnut.2021.805612},
  url = {https://akademik.atauni.edu.tr/yayinlar/209582-tea-tree-oil-terpinen-4-ol-protects-gut-barrier-integrity-by-upregulation-of}
}