Gender specific association of CYP2C9*3 with hyperlipidaemia in Chinese
Özet
Aims To investigate the association of CYP2C9*3 and *6 with hyperlipidaemia in Chinese. Methods Four hundred and seventy-six Chinese participated in the study, including 211 uncomplicated hyperlipidaemic patients and 265 healthy controls. PCR-RFLP was used to identify CYP2C9*3 and *6. Results CYP2C9*6 was not detected in this study. The allelic frequency of CYP2C9*3 was 0.039 (95% CI 0.022, 0.056). A nonsignificant difference existed in CYP2C9*3 frequencies between males and females (P = 0.605, OR = 1.194, 95% CI 0.610, 2.336), patients and controls (P = 0.063, OR = 0.506, 95% CI 0.244, 1.049) in the total population. However, in the female group, CYP2C9*3 frequency in patients with hyperlipidaemia was significantly lower than that in controls (P < 0.0001, OR = 0.062, 95% CI 0.008, 0.476). Conclusions The association of CYP2C9*3 with hyperlipidaemia was specific for females in this Chinese population.
Sürdürülebilir Kalkınma Amaçları
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SKA 3: Sağlıklı Bireyler
Atıf için künye
Luo, C., Wang, A., Zhu, R., Zhang, W., Mo, W., Yu, B., Chen, G., Ou-Yang, D., Duan, X., Hassıbelnaby, A. M. A., & Zhou, H. (2005). Gender specific association of CYP2C9*3 with hyperlipidaemia in Chinese. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 60(6), 629–631. https://doi.org/10.1111/j.1365-2125.2005.02498.x
BibTeX
@article{luo2005-209516,
author = {Luo, CH and Wang, A and Zhu, RH and Zhang, WX and Mo, W and Yu, BN and Chen, GL and Ou-Yang, DS and Duan, XH and Hassıbelnaby, Abdelaty Mostafa Abdelaty and Zhou, HH},
title = {Gender specific association of CYP2C9*3 with hyperlipidaemia in Chinese},
journal = {BRITISH JOURNAL OF CLINICAL PHARMACOLOGY},
year = {2005},
volume = {60},
number = {6},
pages = {629--631},
issn = {0306-5251},
doi = {10.1111/j.1365-2125.2005.02498.x},
url = {https://akademik.atauni.edu.tr/yayinlar/209516-gender-specific-association-of-cyp2c93-with-hyperlipidaemia-in-chinese}
}