Capmatinib attenuates lipogenesis in 3T3-L1 adipocytes through an adenosine monophosphate-activated protein kinase-dependent pathway
Özet
© 2021 Elsevier Inc.Recently, there is a rapid increase in the incidence of obesity, a condition for which there are no effective therapeutic agents. Capmatinib (CAP), a novel mesenchymal-to-epithelial transition inhibitor, is reported to attenuate pro-inflammatory mediators and oxidative stress. In this study, the effects of CAP on lipogenesis in the adipocytes were examined. Treatment with CAP dose-dependently suppressed lipid accumulation in, and differentiation of, and increased lipolysis in, 3T3-L1 adipocytes. Additionally, CAP treatment augmented adenosine monophosphate-activated protein kinase (AMPK) phosphorylation and FNDC5 expression in the adipocytes. Transfection with si-AMPK or si-FNDC5 mitigated the CAP-induced suppression of lipogenesis and enhanced lipolysis. Furthermore, transfection with si-FNDC5 mitigated the CAP-induced phosphorylation of AMPK. These results suggest that the anti-obesity effect of CAP is mediated through the irisin/AMPK pathway and that CAP is a novel therapeutic agent for obesity.
Anahtar kelimeler
Sürdürülebilir Kalkınma Amaçları
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SKA 3: Sağlıklı Bireyler
Atıf için künye
Ahn, S. H., Lee, H. J., Pyun, D. H., Kim, T. J., Hassıbelnaby, A. M. A., Song, J., Shin, Y. K., Jeong, J. H., Park, E. S., & Jung, T. W. (2021). Capmatinib attenuates lipogenesis in 3T3-L1 adipocytes through an adenosine monophosphate-activated protein kinase-dependent pathway. Biochemical and Biophysical Research Communications, 553, 30–36. https://doi.org/10.1016/j.bbrc.2021.03.064
BibTeX
@article{ahn2021-209450,
author = {Ahn, Sung Ho and Lee, Hyun Jung and Pyun, Do Hyeon and Kim, Tae Jin and Hassıbelnaby, Abdelaty Mostafa Abdelaty and Song, Jin-Ho and Shin, Yong Kyoo and Jeong, Ji Hoon and Park, Eon Sub and Jung, Tae Woo},
title = {Capmatinib attenuates lipogenesis in 3T3-L1 adipocytes through an adenosine monophosphate-activated protein kinase-dependent pathway},
journal = {Biochemical and Biophysical Research Communications},
year = {2021},
volume = {553},
pages = {30--36},
issn = {0006-291X},
doi = {10.1016/j.bbrc.2021.03.064},
url = {https://akademik.atauni.edu.tr/yayinlar/209450-capmatinib-attenuates-lipogenesis-in-3t3-l1-adipocytes-through-an-adenosine}
}