Different Biopolymers' Effects on the Evaluation and Characterization of Floating Tablets Prepared by Lyophilization Technique to Improve the Quality Control Parameters

Sevinç Özakar, Rukiye; Özakar, Emrah

doi:10.7317/pk.2022.46.2.145

Makale Tam Makale Uluslararası 2022

Different Biopolymers' Effects on the Evaluation and Characterization of Floating Tablets Prepared by Lyophilization Technique to Improve the Quality Control Parameters

Rukiye Sevinç Özakar, Emrah Özakar

POLYMER-KOREA Cilt 46 · Sayı 2 · ss. 145–158 · 01.03.2022

DOI ile aç

Özet

Conventional oral drug systems are unable to keep drug concentration within the therapeutic range, and administration of the dosage form several times a day can cause significant fluctuations in plasma drug concentration. Therefore, floating drug delivery systems are being developed. In this study, floating tablets with a model drug (ampicillin sodium-Amp.Na) were successfully prepared using different polymers by the lyophilization technique. This study aims to prepare and characterize floating lyophilized tablets to understand the effect of different biopolymers on quality control parameters more clearly. Within the scope of characterization studies, many parameters were evaluated successfully. All tablets showed 24-hour release and had a mesoporous structure, as understood from the Brunauer-Emmett-Teller (BET) analysis. It has been determined from the Fourier transform infrared (FTIR) and X-ray diffraction (XRD) analyses that Amp.Na doesn't interact with excipients and is an amorphous form. These formulations can be used for other drugs in the future, and optimum properties can be easily characterized.

Anahtar kelimeler

DESIGN Fourier transform infrared IN-VITRO EVALUATION X-RAY-DIFFRACTION FORMULATION OPTIMIZATION polymers release kinetics floating tablet lyophilization Brunauer-Emmett-Teller DRUG-DELIVERY SYSTEMS POROUS MATRIX AMPICILLIN CELLULOSE ALGINATE

Sürdürülebilir Kalkınma Amaçları

SKA 3: Sağlıklı Bireyler

Atıf için künye

Sevinç Özakar, R., & Özakar, E. (2022). Different Biopolymers' Effects on the Evaluation and Characterization of Floating Tablets Prepared by Lyophilization Technique to Improve the Quality Control Parameters. POLYMER-KOREA, 46(2), 145–158. https://doi.org/10.7317/pk.2022.46.2.145

BibTeX

@article{sevincozakar2022-20891,
  author = {Sevinç Özakar, Rukiye and Özakar, Emrah},
  title = {Different Biopolymers' Effects on the Evaluation and Characterization of Floating Tablets Prepared by Lyophilization Technique to Improve the Quality Control Parameters},
  journal = {POLYMER-KOREA},
  year = {2022},
  volume = {46},
  number = {2},
  pages = {145--158},
  issn = {0379-153X},
  doi = {10.7317/pk.2022.46.2.145},
  url = {https://akademik.atauni.edu.tr/yayinlar/20891-different-biopolymers-effects-on-the-evaluation-and-characterization-of-floating}
}