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Makale Tam Makale Uluslararası 2018

Effect of metformin/irinotecan-loaded poly-lactic-co-glycolic acid nanoparticles on glioblastoma: in vitro and in vivo studies

ALI TAGHIZADEHGHALEHJOUGHI, Ahmet Hacımüftüoğlu, Meltem Çetin, Afife Büşra Uğur Kaplan, Bianca GALATEANU, Yaroslav MEZHUEV, Ufuk Okkay, Numan Taspinar, Mehmet Taspinar, Abdullah Uyanık, Betül Gündoğdu, Maryam MOHAMMADZADEH, Kemal Alp Nalci, Polychronis Stivaktakis, Aristidis Tsatsakis, Tae Woo JUNG, Ji Hoon JEONG, Abdelaty Mostafa Abdelaty Hassıbelnaby

NANOMEDICINE Cilt 13 · Sayı 13 · ss. 1595–1606 · 01.07.2018
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Özet

Aim: The present study was designed to evaluate the effects of irinotecan hydrochloride (IRI)- or metformin hydrochloride (MET)-loaded poly-lactic-co-glycolic acid (PLGA) nanoparticles (NPs) for the treatment of glioblastoma multiforme using in vitro neuron and U-87 MG glioblastoma cell cultures and in vivo animal model. Methods: The cytotoxic and neurotoxic effects of pure drugs, blank NPs and MET- and IRI-loaded PLGA NPs were investigated in vitro (using methylthiazolyldiphenyl-tetrazolium bromide assay) and in vivo (using Cavalieri's principle for estimation of cancer volume). Results: 1 and 2 mM doses of MET and MET-loaded PLGA NPs, respectively, significantly reduced the volume of extracted cancer. Conclusion: Consequently, MET- and IRI-loaded PLGA NPs may be a promising approach for the treatment of glioblastoma multiforme.

Anahtar kelimeler

brain tumor Cavalieri's principle irinotecan metformin nanoparticles PLGA

Sürdürülebilir Kalkınma Amaçları

  • SKA 3: Sağlıklı Bireyler

Atıf için künye

TAGHIZADEHGHALEHJOUGHI, A., Hacımüftüoğlu, A., Çetin, M., Uğur Kaplan, A. B., GALATEANU, B., MEZHUEV, Y., Okkay, U., Taspinar, N., Taspinar, M., Uyanık, A., Gündoğdu, B., MOHAMMADZADEH, M., Nalci, K. A., Stivaktakis, P., Tsatsakis, A., JUNG, T. W., JEONG, J. H., & Hassıbelnaby, A. M. A. (2018). Effect of metformin/irinotecan-loaded poly-lactic-co-glycolic acid nanoparticles on glioblastoma: in vitro and in vivo studies. NANOMEDICINE, 13(13), 1595–1606. https://doi.org/10.2217/nnm-2017-0386

BibTeX 
@article{taghizadehghalehjoughi2018-20651,
  author = {TAGHIZADEHGHALEHJOUGHI, ALI and Hacımüftüoğlu, Ahmet and Çetin, Meltem and Uğur Kaplan, Afife Büşra and GALATEANU, Bianca and MEZHUEV, Yaroslav and Okkay, Ufuk and Taspinar, Numan and Taspinar, Mehmet and Uyanık, Abdullah and Gündoğdu, Betül and MOHAMMADZADEH, Maryam and Nalci, Kemal Alp and Stivaktakis, Polychronis and Tsatsakis, Aristidis and JUNG, Tae Woo and JEONG, Ji Hoon and Hassıbelnaby, Abdelaty Mostafa Abdelaty},
  title = {Effect of metformin/irinotecan-loaded poly-lactic-co-glycolic acid nanoparticles on glioblastoma: in vitro and in vivo studies},
  journal = {NANOMEDICINE},
  year = {2018},
  volume = {13},
  number = {13},
  pages = {1595--1606},
  issn = {1743-5889},
  doi = {10.2217/nnm-2017-0386},
  url = {https://akademik.atauni.edu.tr/yayinlar/20651-effect-of-metforminirinotecan-loaded-poly-lactic-co-glycolic-acid-nanoparticles}
}