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Makale Tam Makale Uluslararası 2019

Phosphodiesterase-1 inhibitory potential of several natural products by molecular docking approach

Abdur Rauf, Muslim Raza, Muhammad Saleem, İLKAY ERDOĞAN ORHAN, UFUK ÖZGEN, Esen Sezen Karaoğlan, GÜLİN RENDA, ERHAN PALASKA

PHYTOCHEMISTRY LETTERS Cilt 30 · ss. 356–361 · 01.04.2019
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Özet

Natural products of herbal origin are well-known to exhibit diverse biological activities. In the present study, a number of natural compounds of plant origin; luteolin 5-O-beta-glucoside (1), methyl rosmarinate (2), apigenin (3), vicenin 2 (4), lithospermic acid (5), soyasaponin II (6), and rubiadin 3-O-beta-primeveroside (7) were tested at 0.5mM using ELISA microtiter assay against phosphodiesterase-1 (PDE-1), which plays role in smooth muscle activity and inflammation. Among the tested compounds, luteolin 5-O-beta-glucoside (1) (IC50 = 125.01 +/- 1.24 mu M), apigenin (3) (IC50 = 62.50 +/- 1.56 mu M), and rubiadin 3-O-beta-primeveroside (7) (IC50 = 93.75 +/- 2.50 mu M) displayed a strong inhibition as compared to the reference (EDTA, IC50 = 270.11 +/- 2.65 mu M). Besides, the active three compounds (1, 3, and 7) were proceeded to molecular docking experiments using two docking softwares (Autodock Vina and i-GEMDOCK) and showed clear interactions with active gorge of the enzyme through hydrogen bondings as well as hydrophobic contacts.

Anahtar kelimeler

heart Flavonoids Molecular docking Phenolics enzyme inhibition ANTHRAQUINONES Luteolin apigenin Phosphodiesterase CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES SMOOTH-MUSCLE GUINEA-PIG RUBIADIN DATABASE CELL

Atıf için künye

Rauf, A., Raza, M., Saleem, M., ERDOĞAN ORHAN, İ., ÖZGEN, U., Sezen Karaoğlan, E., RENDA, G., & PALASKA, E. (2019). Phosphodiesterase-1 inhibitory potential of several natural products by molecular docking approach. PHYTOCHEMISTRY LETTERS, 30, 356–361. https://doi.org/10.1016/j.phytol.2019.02.026

BibTeX 
@article{rauf2019-20493,
  author = {Rauf, Abdur and Raza, Muslim and Saleem, Muhammad and ERDOĞAN ORHAN, İLKAY and ÖZGEN, UFUK and Sezen Karaoğlan, Esen and RENDA, GÜLİN and PALASKA, ERHAN},
  title = {Phosphodiesterase-1 inhibitory potential of several natural products by molecular docking approach},
  journal = {PHYTOCHEMISTRY LETTERS},
  year = {2019},
  volume = {30},
  pages = {356--361},
  issn = {1874-3900},
  doi = {10.1016/j.phytol.2019.02.026},
  url = {https://akademik.atauni.edu.tr/yayinlar/20493-phosphodiesterase-1-inhibitory-potential-of-several-natural-products-by}
}