Some Bioactivities of Limonium meyeri Extracts and their Separated Compounds

The antimicrobial and tyrosinase enzyme inhibition activities of various extracts and isolated compounds of Limonium meyeri were investigated. Apigenin-7-O-beta-glucuronide and myricetin 3-O-alpha-rhamnoside were isolated from the ethyl acetate fraction using chromatographic methods. Methanol extract showed 62.0% and ethyl acetate extract showed 57.6% tyrosinase enzyme inhibition activities at 400 mu g/mL concentration. Myricetin 3-O-alpha-rhamnoside (IC50 = 27.7 +/- 0.6 mu g/mL) showed higher tyrosinase enzyme inhibitory effect than apigenin-7-O-beta-glucuronide (IC50 = 43.0 +/- 0.9 mu g/mL). n-Hexane extract was found to be effective against Enterococcus faecalis (MIC = 1 mu g/mL), while methanol extract was effective against Pseudomonas aeruginosa (MIC = 16 mu g/mL). Myricetin 3-O-alpha-rhamnoside showed antimicrobial effect against Enterococcus faecalis (MIC = 128 mu g/mL). Thus, Limonium meyeri and its compounds may provide valuable insights for future studies as antityrosinase and antibacterial agents.