Effects of umbelliferone isolated from the Ferulago pauciradiata Boiss. & Heldr. Plant on cecal ligation and puncture-induced sepsis model in rats
Özet
Sepsis is a pathophysiological event involving systemic inflammatory response syndrome, multiple organ failure syndromes, and tissue damage. Overproduction of free radicals as a result of tissue damage during sepsis contributes to cellular toxicity, organ failure, and even mortality. Antioxidants, which scavenge free radicals, play a protective role against various diseases. Previous studies have shown that umbelliferone (UF) has antioxidant and anti-inflammatory effects. Since oxidative stress is naturally associated with sepsis-induced organ dysfunction, the application of antioxidant compounds could potentially illuminate the pathophysiology of sepsis, which does not yet have an effective treatment.
Anahtar kelimeler
Atıf için künye
Kutlu, Z., Çelik, M., Bilen, A., Halıcı, Z., Yıldırım, S., Yıldırım, S., Karakaya, S., Bostanlik, D. F., & Aydin, P. (2020). Effects of umbelliferone isolated from the Ferulago pauciradiata Boiss. & Heldr. Plant on cecal ligation and puncture-induced sepsis model in rats. BIOMEDICINE & PHARMACOTHERAPY, 127. https://doi.org/10.1016/j.biopha.2020.110206
BibTeX
@article{kutlu2020-20260,
author = {Kutlu, Zerrin and Çelik, Muhammet and Bilen, Arzu and Halıcı, Zekai and Yıldırım, Serkan and Yıldırım, Serkan and Karakaya, Songül and Bostanlik, Delimustafaoglu F. and Aydin, P.},
title = {Effects of umbelliferone isolated from the Ferulago pauciradiata Boiss. & Heldr. Plant on cecal ligation and puncture-induced sepsis model in rats},
journal = {BIOMEDICINE & PHARMACOTHERAPY},
year = {2020},
volume = {127},
issn = {0753-3322},
doi = {10.1016/j.biopha.2020.110206},
url = {https://akademik.atauni.edu.tr/yayinlar/20260-effects-of-umbelliferone-isolated-from-the-ferulago-pauciradiata-boiss-heldr}
}