Atatürk Üniversitesi Atatürk Üniversitesi
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Makale Tam Makale Uluslararası 2021

Assesment of hematotoxic, oxidative and genotoxic damage potentials of fipronil in rainbow trout Oncorhynchus mykiss, Walbaum

Arzu Uçar, Veysel Parlak, Asli Cilingir Yeltekin, Fatma Betül Özgeriş, Özge Çağlar, Hasan Türkez, Gonca Alak, Muhammed Atamanalp

TOXICOLOGY MECHANISMS AND METHODS Cilt 31 · Sayı 1 · ss. 73–80 · 01.01.2021
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Özet

In this study, changes in the blood tissue of rainbow trout (Oncorhynchus mykiss, Walbaum, 1792) caused by Fipronil (FP) insecticide were investigated using different biomarkers (Hematology parameters, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), malondialdehyde (MDA), paraoxonase (PON), arylesterase (ARE), myeleperoxidase (MPO), micronucleus (MN), 8-hydroxy-2-deoxyguanosine (8-OHdG)) level and caspase-3 activity. Statistically significant alterations in hematology parameters occurred with FP effect. In blood tissue, dose-dependent inhibition was determined in SOD-CAT-GPX-PON and ARE enzyme activities, but MDA and MPO were induced statistically significant. The results of MN assay were compared with the control group and it was obtained that genotoxicity of different dose groups was similar. The level of 8-OHdG and the activity and caspase-3 examined in blood tissue was increased depending on the dose. It was determined with different biomarkers that this insecticide caused physiological stress changes in the tissues examined.

Anahtar kelimeler

Caspase-3 8-OHdG FIPRONIL HEMATOLOGY O mykiss enzyme parameters

Atıf için künye

Uçar, A., Parlak, V., Cilingir Yeltekin, A., Özgeriş, F. B., Çağlar, Ö., Türkez, H., Alak, G., & Atamanalp, M. (2021). Assesment of hematotoxic, oxidative and genotoxic damage potentials of fipronil in rainbow trout Oncorhynchus mykiss, Walbaum. TOXICOLOGY MECHANISMS AND METHODS, 31(1), 73–80. https://doi.org/10.1080/15376516.2020.1831122

BibTeX 
@article{ucar2021-200854,
  author = {Uçar, Arzu and Parlak, Veysel and Cilingir Yeltekin, Asli and Özgeriş, Fatma Betül and Çağlar, Özge and Türkez, Hasan and Alak, Gonca and Atamanalp, Muhammed},
  title = {Assesment of hematotoxic, oxidative and genotoxic damage potentials of fipronil in rainbow trout Oncorhynchus mykiss, Walbaum},
  journal = {TOXICOLOGY MECHANISMS AND METHODS},
  year = {2021},
  volume = {31},
  number = {1},
  pages = {73--80},
  issn = {1537-6516},
  doi = {10.1080/15376516.2020.1831122},
  url = {https://akademik.atauni.edu.tr/yayinlar/200854-assesment-of-hematotoxic-oxidative-and-genotoxic-damage-potentials-of-fipronil}
}