Hematological and Hepatic Effects of Ulexite in Zebrafish
Özet
The ulexite (UX), a borate mineral, is used as boron source and commonly used in various industrial processes. The hematological and hepatic effects of UX were investigated by exposing adult zebrafish to UX (5, 10, 20 and 40 mg/L) over 96 hours. The blood and liver tissues were taken at the end of the trial period then micronucleus (MN) rates, oxidative DNA damage (8-OHdG), apoptosis (Caspase-3), superoxide dismutase (SOD), catalase (CAT), glutathione pemxidase (GPx), myelopemxidase (MPO), paraoxonase (PON), arylesterase (AR) and lipid peroxidation (MDA) levels were determined. Genotoxic damage by UX occurred only at 40 mg/L in the blood MN assay. Oxidative stress, oxidative DNA damage and apoptosis in liver also occurred at this dose. Moreover, 5-20 mg/L doses led to decreases of DNA damage and apoptosis levels via promoting antioxidant system in liver tissues. UX exhibits beneficial roles on blood and liver tissues of zebrafish at relatively lower doses, which may be relevant to nutritional and medicinal industries.
Anahtar kelimeler
Atıf için künye
Alak, G., Özgeriş, F. B., Yeltekin, A. Ç., Parlak, V., Uçar, A., Caglar, O., Türkez, H., & Atamanalp, M. (2020). Hematological and Hepatic Effects of Ulexite in Zebrafish. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 80, 1. https://doi.org/10.1016/j.etap.2020.103496
BibTeX
@article{alak2020-200853,
author = {Alak, Gonca and Özgeriş, Fatma Betül and Yeltekin, Aslı Çilingir and Parlak, Veysel and Uçar, Arzu and Caglar, Ozge and Türkez, Hasan and Atamanalp, Muhammed},
title = {Hematological and Hepatic Effects of Ulexite in Zebrafish},
journal = {ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY},
year = {2020},
volume = {80},
issn = {1382-6689},
doi = {10.1016/j.etap.2020.103496},
url = {https://akademik.atauni.edu.tr/yayinlar/200853-hematological-and-hepatic-effects-of-ulexite-in-zebrafish}
}