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Makale Tam Makale Uluslararası 2016

Inhibitory effects of benzimidazole containing new phenolic Mannich bases on human carbonic anhydrase isoforms hCA I and II

Halise İnci Gül, Zehra Yazici, Muhammet Tanc, Claudiu T. Supuran

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY Cilt 31 · Sayı 6 · ss. 1540–1544 · 01.01.2016
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Özet

New phenolic mono and bis Mannich bases incorporating benzimidazole, such as 2-(aminomethyl)-4-(1H-benzimidazol-2-yl)phenol and 2,6-bis(aminomethyl)-4-(1H-benzimidazol-2-yl)phenol were synthesized starting from 4-(1H-benzimidazol-2-yl)phenol. Amines used for the synthesis included dimethylamine, pyrrolidine, piperidine, N-methylpiperazine and morpholine. The CA inhibitory properties of these compounds were tested on the human carbonic anhydrase (CA, EC 4.2.1.1) isoforms hCA I and hCA II. These new compounds, as many phenols show moderate CA inhibitory properties.

Anahtar kelimeler

carbonic anhydrase cytotoxicity DERIVATIVES enzyme inhibition MECHANISM Mannich bases CORRESPONDING PIPERIDINOLS JURKAT CELLS HYDROCHLORIDES phenol CELLULAR GLUTATHIONE ACTIVATORS Benzimidazole

Atıf için künye

Gül, H. İ., Yazici, Z., Tanc, M., & Supuran, C. T. (2016). Inhibitory effects of benzimidazole containing new phenolic Mannich bases on human carbonic anhydrase isoforms hCA I and II. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 31(6), 1540–1544. https://doi.org/10.3109/14756366.2016.1156675

BibTeX 
@article{gul2016-19982,
  author = {Gül, Halise İnci and Yazici, Zehra and Tanc, Muhammet and Supuran, Claudiu T.},
  title = {Inhibitory effects of benzimidazole containing new phenolic Mannich bases on human carbonic anhydrase isoforms hCA I and II},
  journal = {JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY},
  year = {2016},
  volume = {31},
  number = {6},
  pages = {1540--1544},
  issn = {1475-6366},
  doi = {10.3109/14756366.2016.1156675},
  url = {https://akademik.atauni.edu.tr/yayinlar/19982-inhibitory-effects-of-benzimidazole-containing-new-phenolic-mannich-bases-on}
}