Makale
Tam Makale
Uluslararası
2018
Synthesis and Cytotoxicities of New Azafluorenones with Apoptotic Mechanism of Action and Cell Cycle Analysis
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
Cilt 18 · Sayı 12 · ss. 1770–1778 · 01.01.2018
Özet
Background: In this study, new azafluorenones, 4-(4-fluorophenyl)-2-(4-substitutedphenyl)-5H-indeno[1,2-b] pyridin-5-one, I1-I8 were synthesized and chemical structures were elucidated by spectral analysis. All compounds were reported for the first time here.
Anahtar kelimeler
apoptosis
cytotoxicity
ALKALOIDS
DERIVATIVES
Synthesis
MONO-MANNICH BASES
cell cycle
PARP
Azafluorenone
OSCC cell line
II INHIBITORY-ACTIVITY
TOPOISOMERASE-I
DNA-BINDING
ANTICANCER ACTIVITY
RATIONAL DESIGN
GLUTAMIC-ACID
THALIDOMIDE
Atıf için künye
Gül, H. İ., TUĞRAK, M., Gül, M., SAKAGAMİ, H., UMEMURA, N., & Anıl, B. (2018). Synthesis and Cytotoxicities of New Azafluorenones with Apoptotic Mechanism of Action and Cell Cycle Analysis. ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 18(12), 1770–1778. https://doi.org/10.2174/1871520618666180525085445
BibTeX
@article{gul2018-19970,
author = {Gül, Halise İnci and TUĞRAK, Mehtap and Gül, Mustafa and SAKAGAMİ, Hiroshi and UMEMURA, Naoki and Anıl, Barış},
title = {Synthesis and Cytotoxicities of New Azafluorenones with Apoptotic Mechanism of Action and Cell Cycle Analysis},
journal = {ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY},
year = {2018},
volume = {18},
number = {12},
pages = {1770--1778},
issn = {1871-5206},
doi = {10.2174/1871520618666180525085445},
url = {https://akademik.atauni.edu.tr/yayinlar/19970-synthesis-and-cytotoxicities-of-new-azafluorenones-with-apoptotic-mechanism-of}
}