Aminoalkylated Phenolic Chalcones: Investigation of Biological Effects on Acetylcholinesterase and Carbonic Anhydrase I and II as Potential Lead Enzyme Inhibitors
Özet
Background: Phenolic Mannich bases have been reported as acetylcholinesterase (AChE) inhibitors for the medication of Alzheimer's disease. Carbonic Anhydrases (CAs) are molecular targets for anticonvulsant, diuretic and antiglaucoma drugs in the clinic. Phenolic compounds have also been mentioned as CA inhibitors. The importance of Mannich bases in drug design inspired our research group to design novel phenolic Mannic bases as potent enzyme inhibitors.
Anahtar kelimeler
Atıf için künye
Yamali, C., Gül, H. İ., Çakır, T., Demir, Y., & Gülçin, İ. (2020). Aminoalkylated Phenolic Chalcones: Investigation of Biological Effects on Acetylcholinesterase and Carbonic Anhydrase I and II as Potential Lead Enzyme Inhibitors. LETTERS IN DRUG DESIGN & DISCOVERY, 17(10), 1283–1292. https://doi.org/10.2174/1570180817999200520123510
BibTeX
@article{yamali2020-19896,
author = {Yamali, Cem and Gül, Halise İnci and Çakır, Tahir and Demir, Yeliz and Gülçin, İlhami},
title = {Aminoalkylated Phenolic Chalcones: Investigation of Biological Effects on Acetylcholinesterase and Carbonic Anhydrase I and II as Potential Lead Enzyme Inhibitors},
journal = {LETTERS IN DRUG DESIGN & DISCOVERY},
year = {2020},
volume = {17},
number = {10},
pages = {1283--1292},
issn = {1570-1808},
doi = {10.2174/1570180817999200520123510},
url = {https://akademik.atauni.edu.tr/yayinlar/19896-aminoalkylated-phenolic-chalcones-investigation-of-biological-effects-on}
}