Monoamine Oxidase (MAO) as a Potential Target for Anticancer Drug Design and Development.

Aljanabi, Reem; Alsous, Lina; Sabbah, Dima A; Gül, Halise İnci; Gül, Mustafa; Bardaweel, Sanaa K

doi:10.3390/molecules26196019

Makale Tam Makale Uluslararası 2021 Açık erişimli

Monoamine Oxidase (MAO) as a Potential Target for Anticancer Drug Design and Development.

Reem Aljanabi, Lina Alsous, Dima A Sabbah, Halise İnci Gül, Mustafa Gül, Sanaa K Bardaweel

MOLECULES Cilt 26 · Sayı 19 · 04.10.2021

DOI ile aç

Özet

Monoamine oxidases (MAOs) are oxidative enzymes that catalyze the conversion of biogenic amines into their corresponding aldehydes and ketones through oxidative deamination. Owing to the crucial role of MAOs in maintaining functional levels of neurotransmitters, the implications of its distorted activity have been associated with numerous neurological diseases. Recently, an unanticipated role of MAOs in tumor progression and metastasis has been reported. The chemical inhibition of MAOs might be a valuable therapeutic approach for cancer treatment. In this review, we reported computational approaches exploited in the design and development of selective MAO inhibitors accompanied by their biological activities. Additionally, we generated a pharmacophore model for MAO-A active inhibitors to identify the structural motifs to invoke an activity.

Anahtar kelimeler

CANCER INHIBITORS LUNG-CANCER Molecular docking BIOLOGICAL-ACTIVITIES MEDICINAL CHEMISTRY monoamine oxidase metastasis QSAR pharmacophore QUANTITATIVE STRUCTURE-ACTIVITY INHIBITORY-ACTIVITY PROSTATE-CANCER MESENCHYMAL TRANSITION SELECTIVE INHIBITORS PYRROLE INHIBITORS

Sürdürülebilir Kalkınma Amaçları

SKA 3: Sağlıklı Bireyler

Atıf için künye

Aljanabi, R., Alsous, L., Sabbah, D. A., Gül, H. İ., Gül, M., & Bardaweel, S. K. (2021). Monoamine Oxidase (MAO) as a Potential Target for Anticancer Drug Design and Development. MOLECULES, 26(19). https://doi.org/10.3390/molecules26196019

BibTeX

@article{aljanabi2021-19888,
  author = {Aljanabi, Reem and Alsous, Lina and Sabbah, Dima A and Gül, Halise İnci and Gül, Mustafa and Bardaweel, Sanaa K},
  title = {Monoamine Oxidase (MAO) as a Potential Target for Anticancer Drug Design and Development.},
  journal = {MOLECULES},
  year = {2021},
  volume = {26},
  number = {19},
  issn = {1420-3049},
  doi = {10.3390/molecules26196019},
  url = {https://akademik.atauni.edu.tr/yayinlar/19888-monoamine-oxidase-mao-as-a-potential-target-for-anticancer-drug-design-and}
}