Synthesis of some acrylophenones with N-methylpiperazine and evaluation of their cytotoxicities
Özet
In this study, the compounds having acrylophenone structure, 1-aryl-2-(N-methylpiperazinomethyl)-2-propen-1-one dihydrochlorides, were synthesized and their chemical structures were identified with H-1 NMR, C-13 NMR and HRMS spectra. The cytotoxicities of the compounds were tested towards Ca9-22 (human gingival carcinoma), HSC-2 (human oral squamous carcinoma), HSC-3 (human oral squamous carcinoma) and HSC-4 (human oral squamous carcinoma) cell lines as tumor cell lines and HGF (gingival fibroblasts), HPLF (periodontal ligament fibroblasts) and HPC (pulp cells) cell lines as non-tumor cell lines. PSE of the compound TA2, which has a methyl substituent on phenyl ring, pointed out the compound TA2 as a leader compound to be considered.
Anahtar kelimeler
Atıf için künye
Gül, H. İ., TUĞRAK, M., & Sakagami, H. (2016). Synthesis of some acrylophenones with N-methylpiperazine and evaluation of their cytotoxicities. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 31(1), 147–151. https://doi.org/10.3109/14756366.2015.1014474
BibTeX
@article{gul2016-19875,
author = {Gül, Halise İnci and TUĞRAK, Mehtap and Sakagami, Hiroshi},
title = {Synthesis of some acrylophenones with N-methylpiperazine and evaluation of their cytotoxicities},
journal = {JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY},
year = {2016},
volume = {31},
number = {1},
pages = {147--151},
issn = {1475-6366},
doi = {10.3109/14756366.2015.1014474},
url = {https://akademik.atauni.edu.tr/yayinlar/19875-synthesis-of-some-acrylophenones-with-n-methylpiperazine-and-evaluation-of-their}
}