Synthesis of 3-aroyl-4-aryl-1-isopropylamino-4-piperidinols and evaluation of the cytotoxicities of the compounds against human hepatoma and breast cancer cell lines
Özet
Some 4-piperidinol derivatives were synthesized and their cytotoxicity was tested against human hepatoma (Huh7) and breast cancer (T47D) cells. Aryl part was changed as phenyl in 2a, 4-methylphenyl in 2b, 4-methoxyphenyl in 2c, 4-chlorophenyl in 2d, 4-fluorophenyl in 2e, 4-bromophenyl in 2f, 4-nitrophenyl in 2g and 2-thienyl in 3. Compounds were synthesized and reported for the first time by this study except 2a and 2d. Chemical structures were confirmed by H-1 NMR, C-13 NMR, IR, MS and elemental analyses. Compounds 2a (3.1 times), 2c (3.8 times), 2f (4.6 times), 2g (1.3 times) and 3 (3.2 times) had 1.3-4.6 times higher cytotoxic potency than the reference compound 5-FU against Huh7 cell line while all the compounds synthesized had shown lower activities against T47D cell line than 5-FU. In the light of these results, compounds 2a, 2c, 2f, 2g and 3 may serve as model compounds for further studies.
Anahtar kelimeler
Sürdürülebilir Kalkınma Amaçları
-
SKA 3: Sağlıklı Bireyler
Atıf için künye
Kucukoglu, K., Mete, E., Cetin-Atalay, R., & Gül, H. İ. (2015). Synthesis of 3-aroyl-4-aryl-1-isopropylamino-4-piperidinols and evaluation of the cytotoxicities of the compounds against human hepatoma and breast cancer cell lines. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 30(4), 564–568. https://doi.org/10.3109/14756366.2014.951350
BibTeX
@article{kucukoglu2015-19873,
author = {Kucukoglu, Kaan and Mete, Ebru and Cetin-Atalay, Rengul and Gül, Halise İnci},
title = {Synthesis of 3-aroyl-4-aryl-1-isopropylamino-4-piperidinols and evaluation of the cytotoxicities of the compounds against human hepatoma and breast cancer cell lines},
journal = {JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY},
year = {2015},
volume = {30},
number = {4},
pages = {564--568},
issn = {1475-6366},
doi = {10.3109/14756366.2014.951350},
url = {https://akademik.atauni.edu.tr/yayinlar/19873-synthesis-of-3-aroyl-4-aryl-1-isopropylamino-4-piperidinols-and-evaluation-of}
}