Treatment with Carnitine Enhances Bone Fracture Healing under Osteoporotic and/or Inflammatory Conditions
Özet
The aim of this study was to examine the effects of carnitine on bone healing in ovariectomy (OVX) and inflammation (INF)-induced osteoporotic rats. The rats were randomly divided into nine groups (n=8 animals per group): sham-operated (Group 1: SHAM); sham+magnesium silicate (Mg-silicate) (Group 2: SHAM+INF); ovariectomy (Group 3: OVX); ovariectomy+femoral fracture (Group 4: OVX+FRC); ovariectomy+femoral fracture+Mg-silicate (Group 5: OVX+FRC+INF); ovariectomy+femoral fracture+carnitine 50mg/kg (Group 6: OVX+FRC+CAR50); ovariectomy+femoral fracture+carnitine 100mg/kg (Group 7: OVX+FRC+CAR100); ovariectomy+femoral fracture+Mg-silicate+carnitine 50mg/kg (Group 8: OVX+FRC+INF+CAR50); and ovariectomy+femoral fracture+Mg-silicate+carnitine 100mg/kg (Group 9: OVX+FRC+INF+CAR100). Eight weeks after OVX, which allowed for osteoporosis to develop, INF was induced with subcutaneous Mg-silicate. On day 80, all of the rats in groups 4-9 underwent fracture operation on the right femur. Bone mineral density (BMD) showed statistically significant improvements in the treatment groups. The serum markers of bone turnover (osteocalcin and osteopontin) and pro-inflammatory cytokines (tumour necrosis factor , interleukin 1 and interleukin 6) were decreased in the treatment group. The X-ray images showed significantly increased callus formation and fracture healing in the groups treated with carnitine. The present results show that in a rat model with osteoporosis induced by ovariectomy and Mg-silicate, treatment with carnitine improves the healing of femur fractures.
Atıf için künye
Aydın, A., Halıcı, Z., Albayrak, A., Erkayman, B., Karakus, E., Yıldırım, Ö. S., Bayır, Y., Çadırcı, E., Ayan, A. K., & AKSAKAL, A. M. (2015). Treatment with Carnitine Enhances Bone Fracture Healing under Osteoporotic and/or Inflammatory Conditions. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 117(3), 173–179. https://doi.org/10.1111/bcpt.12384
BibTeX
@article{aydin2015-19600,
author = {Aydın, Ali and Halıcı, Zekai and Albayrak, Abdulmecit and Erkayman, Beyzagül and Karakus, Emre and Yıldırım, Ömer Selim and Bayır, Yasin and Çadırcı, Elif and Ayan, Arif Kürşad and AKSAKAL, Ahmet Murat},
title = {Treatment with Carnitine Enhances Bone Fracture Healing under Osteoporotic and/or Inflammatory Conditions},
journal = {BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY},
year = {2015},
volume = {117},
number = {3},
pages = {173--179},
issn = {1742-7835},
doi = {10.1111/bcpt.12384},
url = {https://akademik.atauni.edu.tr/yayinlar/19600-treatment-with-carnitine-enhances-bone-fracture-healing-under-osteoporotic-andor}
}