Cytotoxic naphthoquinones fromArnebia densiflora(Nordm.) Ledeb and determining new apoptosis inducers
Özet
In this study, phytochemical composition ofArnebia densiflora(AD) was determined and cytotoxic effects of then-hexane extract and compounds isolated from this species on various cell lines were investigated. By means of serial chromatographic studies, 6 naphthoquinone derivatives were yielded, which are isovalerylalkannin,alpha-methyl-n-butyl alkannin, acetylalkannin,beta-acetoxy isovalerylalkannin, alkannin and a new compound: 4-hydroxy 4-methyl valeryl alkannin. Structures of the isolated compounds were elucidated using UV, IR, 1D-2D NMR, MS and CD methods. Cytotoxic effects of the extract and isolated alkannins were investigated on L929, HeLa, HEp-2 cells. AD and the isolated compounds demonstrated moderate to strong cytotoxic effects (IC(50)range: 4.92-172.35 mu g/ml). The results of DNA fragmentation and caspase-3 activity studies on HeLa cells exhibited that AD and the naphthoquinones isolated from it caused cytotoxicity through induction of apoptosis.
Anahtar kelimeler
Atıf için künye
Baran, M. Y., Güvenalp, Z., SARAÇOĞLU, İ., Kazaz, C., SALİH, B., DEMİREZER, L. Ö., & Kuruuzum-Uz, A. (2020). Cytotoxic naphthoquinones fromArnebia densiflora(Nordm.) Ledeb and determining new apoptosis inducers. NATURAL PRODUCT RESEARCH, 34(12), 1669–1677. https://doi.org/10.1080/14786419.2018.1525714
BibTeX
@article{baran2020-18990,
author = {Baran, Merve Yuzbasioglu and Güvenalp, Zühal and SARAÇOĞLU, İCLAL and Kazaz, Cavit and SALİH, BEKİR and DEMİREZER, LÜTFİYE ÖMÜR and Kuruuzum-Uz, Ayse},
title = {Cytotoxic naphthoquinones fromArnebia densiflora(Nordm.) Ledeb and determining new apoptosis inducers},
journal = {NATURAL PRODUCT RESEARCH},
year = {2020},
volume = {34},
number = {12},
pages = {1669--1677},
issn = {1478-6419},
doi = {10.1080/14786419.2018.1525714},
url = {https://akademik.atauni.edu.tr/yayinlar/18990-cytotoxic-naphthoquinones-fromarnebia-densifloranordm-ledeb-and-determining-new}
}