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Makale Tam Makale Uluslararası 2015

Cytotoxic Compounds from Endemic Arnebia purpurea

Merve Yuzbasioglu, Ayse Kuruuzum-Uz, Zühal Güvenalp, Andras SIMON, Gabor TOTH, U. Sebnem Harput, Cavit Kazaz, Bilgehan Bilgili, Hayri Duman, İCLAL SARAÇOĞLU, L. Omur Demirezer

NATURAL PRODUCT COMMUNICATIONS Cilt 10 · Sayı 4 · ss. 595–596 · 01.04.2015

Özet

Phytochemical studies of the roots and aerial parts of endemic Arnebia purpurea S. Erik & H. Sumbul resulted in the isolation and characterization of four naphthoquinones [isovalerylalkannin (1), alpha-methyl-n-butanoyl alkannin (2), acetylalkannin (3), and alkannin (4)], a triterpene derivative [3-O-acetyl-oleanolic acid (5)], a steroid [beta-sitosterol (6)], three flavonoid glycosides [isorhamnetin-3-O-rutinoside (7), kaempferol-3-O-rutinoside (8), kaempferol 3-O-(5 ''-acetyl) apiofuranoside 7-O-rhamnopyranoside (9)] and a phenolic acid [rosmarinic acid (10)]. 3-O-Acetyl-oleanolic acid, isorhamnetin-3-O-rutinoside, kaempferol-3-O-rutinoside, and kaempferol 3-O-(5 ''-acetyl) apiofuranoside 7-O-rhamnopyranoside are reported from an Arnebia species for the first time. Cytotoxic activities on L929 murine fibrosarcoma cell line of the isolated compounds were investigated using MTT assay. Naphthoquinones (1-4) showed intermediate cytotoxic activity in comparison with the standard, doxorubicin.

Anahtar kelimeler

antioxidant cytotoxicity Flavonoids Boraginaceae Arnebia purpurea Naphthoquinones Triterpenes Steroids Rosmarinic acid SHIKONIN

Atıf için künye

Yuzbasioglu, M., Kuruuzum-Uz, A., Güvenalp, Z., SIMON, A., TOTH, G., Harput, U. S., Kazaz, C., Bilgili, B., Duman, H., SARAÇOĞLU, İ., & Demirezer, L. O. (2015). Cytotoxic Compounds from Endemic Arnebia purpurea. NATURAL PRODUCT COMMUNICATIONS, 10(4), 595–596.

BibTeX 
@article{yuzbasioglu2015-18970,
  author = {Yuzbasioglu, Merve and Kuruuzum-Uz, Ayse and Güvenalp, Zühal and SIMON, Andras and TOTH, Gabor and Harput, U. Sebnem and Kazaz, Cavit and Bilgili, Bilgehan and Duman, Hayri and SARAÇOĞLU, İCLAL and Demirezer, L. Omur},
  title = {Cytotoxic Compounds from Endemic Arnebia purpurea},
  journal = {NATURAL PRODUCT COMMUNICATIONS},
  year = {2015},
  volume = {10},
  number = {4},
  pages = {595--596},
  issn = {1934-578X},
  url = {https://akademik.atauni.edu.tr/yayinlar/18970-cytotoxic-compounds-from-endemic-arnebia-purpurea}
}