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Makale Tam Makale Uluslararası 2013

Determination of antimutagenic properties of apigenin-7-O-rutinoside, a flavonoid isolated from Mentha longifolia (L.) Huds. ssp longifolia with yeast DEL assay

Medine GÜLLÜCE, Furkan ORHAN, Ahmet Adıgüzel, Tuğba Bal, Zühal Güvenalp, Lutfiye Omur Dermirezer

TOXICOLOGY AND INDUSTRIAL HEALTH Cilt 29 · Sayı 6 · ss. 534–540 · 01.07.2013
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Özet

Lamiaceae is an important plant family that has been investigated for its medicinal properties due to its large amounts of phenolic acids and flavonoids. Flavonoids have been shown to have antioxidant and antimutagenic activities in different test systems, but their certain mechanisms are still unclear. This study was designed to evaluate the mutagenic and antimutagenic activities of apigenin 7-O-rutinoside, a flavonoid isolated from Mentha longifolia (L.) Huds. ssp. longifolia. The possible antimutagenic potential of apigenin 7-O-rutinoside (A7R) was examined against mutagens ethyl methanesulfonate (EMS) and acridine (AC) in a eukaryotic cell system Saccharomyces cerevisiae RS112. The results showed that A7R has different inhibition rates against EMS and AC-induced mutagenicity. Thus, the properties of A7R are of great pharmacological importance and might be beneficial for reducing the risk of reactive oxygen species-related diseases.

Anahtar kelimeler

ANTIOXIDANT ACTIVITY GENOTOXICITY EXTRACTS Antimutagenicity yeast DEL assay CARCINOGENS apigenin Mentha longifolia Saccharomyces cerevisiae RS112 HAMSTER V79 CELLS INTRACHROMOSOMAL RECOMBINATION DNA-DAMAGE

Atıf için künye

GÜLLÜCE, M., ORHAN, F., Adıgüzel, A., Bal, T., Güvenalp, Z., & Dermirezer, L. O. (2013). Determination of antimutagenic properties of apigenin-7-O-rutinoside, a flavonoid isolated from Mentha longifolia (L.) Huds. ssp longifolia with yeast DEL assay. TOXICOLOGY AND INDUSTRIAL HEALTH, 29(6), 534–540. https://doi.org/10.1177/0748233712442732

BibTeX 
@article{gulluce2013-18967,
  author = {GÜLLÜCE, Medine and ORHAN, Furkan and Adıgüzel, Ahmet and Bal, Tuğba and Güvenalp, Zühal and Dermirezer, Lutfiye Omur},
  title = {Determination of antimutagenic properties of apigenin-7-O-rutinoside, a flavonoid isolated from Mentha longifolia (L.) Huds. ssp longifolia with yeast DEL assay},
  journal = {TOXICOLOGY AND INDUSTRIAL HEALTH},
  year = {2013},
  volume = {29},
  number = {6},
  pages = {534--540},
  issn = {0748-2337},
  doi = {10.1177/0748233712442732},
  url = {https://akademik.atauni.edu.tr/yayinlar/18967-determination-of-antimutagenic-properties-of-apigenin-7-o-rutinoside-a-flavonoid}
}