Inhibitory potential on key enzymes relevant to type II diabetes mellitus and antioxidant properties of the various extracts and phytochemical constituents fromRumex acetosellaL

Type II diabetes mellitus is a common and costly disease worldwide, characterized by hyperglycemia. Alpha (alpha)-amylase and alpha-glucosidase are important targets in diabetes therapy. Inhibition of these enzymes may lessen hyperglycemia, preventing diabetic complications. Oxidative stress is another factor involved in the disease's etiology. In the present study, we investigated antidiabetic profiles of the various extracts and phytochemicals ofRumex acetosella. Since the plant has been traditionally used for the antidiabetic purposes.alpha-amylase and alpha-glucosidase inhibitory studies in addition to DPPH center dot, ABTS center dot+,NO2-radical scavenging, and phosphomolybdate antioxidant assays were performed to evaluate the antidiabetic property. Specifically, the ethanol and ethanol-water extracts remarkably inhibited alpha-glucosidase than that of acarbose, unlike their slight/no inhibition on alpha-amylase. Convincing alpha-glucosidase inhibitory and antioxidant potential of alcohol-including extracts verified the ethnobotanical use ofR. acetosellaas an antidiabetic agent.