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Makale Tam Makale Uluslararası 2026

Phytochemical evaluation via GC-MS and LC-MS/MS: a comprehensive study of antidiabetic, antimicrobial, antioxidant, and genotoxic activities of extracts from endemic species Centaurea amanicola Hub.-Mor. and C. antitauri Hayek (Asteraceae)

Mohaddeseh Nobarirezaeyeh, Hafize Yuca, BİLGE AYDIN, Ayşe Civaş, Songül Karakaya, Mehmet Karadayı, ABDUSSAMED YASİN DEMİR, Mehmet BONA, Bilal Yılmaz, Gamze Göger, Muhammed Ziya Şahinöz, Elif Beyza Özer, Enes Tekman, Zühal Güvenalp, Ayşe Mine Gençler Özkan

NATURAL PRODUCT RESEARCH Cilt 40 · Sayı 3 · ss. 776–785 · 01.01.2026
DOI ile aç

Özet

The study investigated the antidiabetic, antimicrobial, antioxidant, and genotoxic activities of extracts from Centaurea amanicola and C. antitauri (Asteraceae). Methanol extracts were analysed for phenolic and fatty oil contents. Major components of fatty oils were identified, including methyl hexadecanoate (48.30%) and heptacosane (22.13%) in C. antitauri, and methyl hexadecanoate (16.29%) and methyl linoleate (13.55%) in C. amanicola. The highest α-amylase inhibition was observed in hexane extracts of both species with 55.53% and 41.57% inhibition values, respectively. Antioxidant activity, measured by ABTS•+ and DPPH• scavenging, varied among extracts, with notable efficacy in C. antitauri dichloromethane extract and C. amanicola ethyl acetate extract. The dichloromethane extract of C. antitauri demonstrated effectiveness against Candida albicans with MIC= 156.25 µg/mL. Importantly, all extracts were found to be genotoxicity-safe. Overall, the findings highlight the potential of these extracts for various medicinal applications, particularly in managing diabetes and combating microbial infections.

Anahtar kelimeler

GENOTOXICITY antioxidant antidiabetic antimicrobial Centaurea amanicola Centaurea antitauri chemical profiling

Sürdürülebilir Kalkınma Amaçları

  • SKA 3: Sağlıklı Bireyler

Atıf için künye

Nobarirezaeyeh, M., Yuca, H., AYDIN, B., Civaş, A., Karakaya, S., Karadayı, M., DEMİR, A. Y., BONA, M., Yılmaz, B., Göger, G., Şahinöz, M. Z., Özer, E. B., Tekman, E., Güvenalp, Z., & Gençler Özkan, A. M. (2026). Phytochemical evaluation via GC-MS and LC-MS/MS: a comprehensive study of antidiabetic, antimicrobial, antioxidant, and genotoxic activities of extracts from endemic species Centaurea amanicola Hub.-Mor. and C. antitauri Hayek (Asteraceae). NATURAL PRODUCT RESEARCH, 40(3), 776–785. https://doi.org/10.1080/14786419.2024.2425798

BibTeX 
@article{nobarirezaeyeh2026-18550,
  author = {Nobarirezaeyeh, Mohaddeseh and Yuca, Hafize and AYDIN, BİLGE and Civaş, Ayşe and Karakaya, Songül and Karadayı, Mehmet and DEMİR, ABDUSSAMED YASİN and BONA, Mehmet and Yılmaz, Bilal and Göger, Gamze and Şahinöz, Muhammed Ziya and Özer, Elif Beyza and Tekman, Enes and Güvenalp, Zühal and Gençler Özkan, Ayşe Mine},
  title = {Phytochemical evaluation via GC-MS and LC-MS/MS: a comprehensive study of antidiabetic, antimicrobial, antioxidant, and genotoxic activities of extracts from endemic species Centaurea amanicola Hub.-Mor. and C. antitauri Hayek (Asteraceae)},
  journal = {NATURAL PRODUCT RESEARCH},
  year = {2026},
  volume = {40},
  number = {3},
  pages = {776--785},
  issn = {1478-6419},
  doi = {10.1080/14786419.2024.2425798},
  url = {https://akademik.atauni.edu.tr/yayinlar/18550-phytochemical-evaluation-via-gc-ms-and-lc-msms-a-comprehensive-study-of}
}