Evaluation of the Antimicrobial, Antioxidant, Anticholinesterase, and Antidiabetic Activities of Matricaria chamomilla, Lavandula angustifolia, Hypericum perforatum, Salvia officinalis, and Foeniculum vulgare Extracts
Özet
This study evaluated and compared the antimicrobial, antioxidant, anticholinesterase, and antidiabetic activities of Matricaria chamomilla L. (chamomile), Lavandula angustifolia Mill. (lavender), Hypericum perforatum L. (St. John’s wort), Salvia officinalis L. (sage), and Foeniculum vulgare
Mill. (fennel) plants and their extracts. Antioxidant activity was
assessed using DPPH and ABTS assays, while α-glucosidase and α-amylase
inhibition assays determined antidiabetic potential.
Acetylcholinesterase and butyrylcholinesterase inhibitory activities
were measured via the Ellman method, and antimicrobial activity was
evaluated using the micro-well dilution test. Among the tested extracts,
H. perforatum extract and H. perforatum drug exhibited the most potent biological activities. In the α-glucosidase inhibition assay, H. perforatum extract displayed the highest inhibition (95.40%, IC₅₀ = 8 µg/mL), followed by H. perforatum
drug (94.71%, IC₅₀ = 27 µg/mL). The strongest α-amylase inhibition was
observed with the Soothing Complex Product (60.90%), following acarbose
(74.61%). The highest ABTS radical scavenging activity was noted in S. officinalis drug (99.39%) and H. perforatum drug (99.32%), while the DPPH assay showed significant activity for S. officinalis extract (46.99%) and α-tocopherol (46.99%). Antimicrobial testing revealed moderate antibacterial effects of F. vulgare drug against Staphylococcus aureus and Candida albicans (MIC = 1250 µg/mL). Overall, H. perforatum
extracts demonstrated strong enzyme inhibition and antioxidant
properties, highlighting their potential for medicinal and dermocosmetic
applications. These findings provide valuable insights into the
bioactivity of herbal extracts, supporting their potential use in
over-the-counter formulations and new plant-based therapeutic products.
Sürdürülebilir Kalkınma Amaçları
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SKA 15: Karasal Yaşam
Atıf için künye
Uğurlu, M., Yuca, H., Çoban, F., Aydın, B., Göger, G., & Karakaya, S. (2025). Evaluation of the Antimicrobial, Antioxidant, Anticholinesterase, and Antidiabetic Activities of Matricaria chamomilla, Lavandula angustifolia, Hypericum perforatum, Salvia officinalis, and Foeniculum vulgare Extracts. Turkish Journal of Agriculture - Food Science and Technology, 13(7), 1854–1871. https://agrifoodscience.com/index.php/TURJAF/article/view/7631
BibTeX
@article{ugurlu2025-18530,
author = {Uğurlu, Meryem and Yuca, Hafize and Çoban, Furkan and Aydın, Bilge and Göger, Gamze and Karakaya, Songül},
title = {Evaluation of the Antimicrobial, Antioxidant, Anticholinesterase, and Antidiabetic Activities of Matricaria chamomilla, Lavandula angustifolia, Hypericum perforatum, Salvia officinalis, and Foeniculum vulgare Extracts},
journal = {Turkish Journal of Agriculture - Food Science and Technology},
year = {2025},
volume = {13},
number = {7},
pages = {1854--1871},
issn = {2148-127X},
url = {https://akademik.atauni.edu.tr/yayinlar/18530-evaluation-of-the-antimicrobial-antioxidant-anticholinesterase-and-antidiabetic}
}