The discovery of potential anticholinesterase compounds from Achillea millefolium L.

SEVINDIK, Handan Gökben; Güvenalp, Zühal; Yerdelen, Kadir Özden; Yuca, Hafize; DEMİREZER, LÜTFİYE ÖMÜR

doi:10.1016/j.indcrop.2015.05.088

Makale Tam Makale Uluslararası 2015

The discovery of potential anticholinesterase compounds from Achillea millefolium L.

Handan Gökben SEVINDIK, Zühal Güvenalp, Kadir Özden Yerdelen, Hafize Yuca, LÜTFİYE ÖMÜR DEMİREZER

INDUSTRIAL CROPS AND PRODUCTS Cilt 76 · ss. 873–879 · 01.12.2015

DOI ile aç

Özet

Luteolin (1), apigenin-7-0-13-beta-glucoside (2), luteolin 7-beta-13-D-glucoside (3), 6-OH-luteolin glucoside (4) were isolated from Achillea millefolium L. These flavonoids and different polarity fractions of methanol extract from aerial parts of the plant were investigated in terms of antioxidant and anticholinesterase effect. The n-butanol fraction possessed the highest inhibitory activity against acetylcholinesterase (51.3%) while lower inhibitory activity against butyrylcholinesterase (23.5%) as compared with a reference compound, neostigmine (100 and 98.5%), at 25 pg/mL. Compound 4 was exhibited in slum and in vitro the strongest inhibition to AChE and BuChE with IC50 values of 1.65 and 1.97 mu M, respectively and also have strongest antioxidant capacity. Docking simulations revealed that the most potent inhibitor compound 4 targeted both the catalytic and the peripheral active sites of AChE and BuChE with many hydrogen bond interactions. The ethyl acetate fraction has the richest phenolic content (224.6 GAE/mg ext). The mean amount of total flavonoids was 1.65% (calculated as rutin). (C) 2015 Elsevier B.V. All rights reserved.

Anahtar kelimeler

DISEASE total antioxidant capacity Turkey ANTIOXIDANT ACTIVITY CHEMICAL-COMPOSITION phenolic compounds AChE Achillea millefolium BuChE Radical scavenging Flavonoids SESQUITERPENE LACTONE ALZHEIMERS DERIVATIVES GLYCOSIDES

Atıf için künye

SEVINDIK, H. G., Güvenalp, Z., Yerdelen, K. Ö., Yuca, H., & DEMİREZER, L. Ö. (2015). The discovery of potential anticholinesterase compounds from Achillea millefolium L. INDUSTRIAL CROPS AND PRODUCTS, 76, 873–879. https://doi.org/10.1016/j.indcrop.2015.05.088

BibTeX

@article{sevindik2015-18518,
  author = {SEVINDIK, Handan Gökben and Güvenalp, Zühal and Yerdelen, Kadir Özden and Yuca, Hafize and DEMİREZER, LÜTFİYE ÖMÜR},
  title = {The discovery of potential anticholinesterase compounds from Achillea millefolium L.},
  journal = {INDUSTRIAL CROPS AND PRODUCTS},
  year = {2015},
  volume = {76},
  pages = {873--879},
  issn = {0926-6690},
  doi = {10.1016/j.indcrop.2015.05.088},
  url = {https://akademik.atauni.edu.tr/yayinlar/18518-the-discovery-of-potential-anticholinesterase-compounds-from-achillea}
}