α-amylase and α-glucosidase inhibitory activities of the extracts and constituents of ferulago blancheana, F. Pachyloba and F. Trachycarpa roots
Özet
Eleven coumarins named osthole (1), imperatorin (2), bergapten (3), prants-chimgin (4), grandivitinol (5), suberosin (6), xanthotoxin (7), felamidin (8), marmesin (9), umbelliferone (10), ulopterol (11), and a sterol mixture consisted of stigmasterol (12), beta-sitosterol (13) were isolated from the roots of Ferulago blancheana, F. pachyloba and F. trachycarpa through in vitro bioassay-guided fractionation processes. The extracts and bioactive compounds were evaluated for their alpha-amylase and alpha-glucosidase activities. Among the tested compounds, felamidin and suberosin showed significant alpha-glucosidase inhibitory activity with IC50 values of 0.4 and 0.9 mg/mL, respectively, when compared to the reference standard acarbose (IC50 = 4.9 mg/mL). Grandivitinol (IC50 = 20.0 mg/mL) had the lowest inhibitory effect. On the other hand, none of the tested extracts were found to be active on alpha-amylase inhibition. This is the first report on isolation, characterization of the bioactive compounds and evaluation the alpha-amylase and alpha-glucosidase inhibitory activities of these species.
Atıf için künye
Karakaya, S., Özbek, H., GÖZCÜ, S., Güvenalp, Z., Yuca, H., Duman, H., Kazaz, C., & Kilic, C. S. (2018). α-amylase and α-glucosidase inhibitory activities of the extracts and constituents of ferulago blancheana, F. Pachyloba and F. Trachycarpa roots. Bangladesh Journal of Pharmacology, 13(1), 35–40. https://doi.org/10.3329/bjp.v13i1.33668
BibTeX
@article{karakaya2018-18513,
author = {Karakaya, Songül and Özbek, Hilal and GÖZCÜ, SEFA and Güvenalp, Zühal and Yuca, Hafize and Duman, Hayri and Kazaz, Cavit and Kilic, Ceyda Sibel},
title = {α-amylase and α-glucosidase inhibitory activities of the extracts and constituents of ferulago blancheana, F. Pachyloba and F. Trachycarpa roots},
journal = {Bangladesh Journal of Pharmacology},
year = {2018},
volume = {13},
number = {1},
pages = {35--40},
issn = {1991-007X},
doi = {10.3329/bjp.v13i1.33668},
url = {https://akademik.atauni.edu.tr/yayinlar/18513-a-amylase-and-a-glucosidase-inhibitory-activities-of-the-extracts-and}
}